有哪些信誉好的足球投注网站a double-blind, placebo-controlled, randomized, clinical trial of the tlr-3 agonist rintatolimod in severe cases of chronic fatigue syndrome一项双盲、安慰剂对照、随机临床试验的tlr-3兴奋剂rintatolimod慢性疲劳综合症的严重病例.pdfVIP
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a double-blind, placebo-controlled, randomized, clinical trial of the tlr-3 agonist rintatolimod in severe cases of chronic fatigue syndrome一项双盲、安慰剂对照、随机临床试验的tlr-3兴奋剂rintatolimod慢性疲劳综合症的严重病例
A Double-Blind, Placebo-Controlled, Randomized,
Clinical Trial of the TLR-3 Agonist Rintatolimod in Severe
Cases of Chronic Fatigue Syndrome
1 1 2 3 4
David R. Strayer *, William A. Carter , Bruce C. Stouch , Staci R. Stevens , Lucinda Bateman , Paul J.
5 6 7
Cimoch , Charles W. Lapp , Daniel L. Peterson , the Chronic Fatigue Syndrome AMP-516 Study Group ,
William M. Mitchell8*
1 Hemispherx Biopharma, Inc., Philadelphia, Pennsylvania, United States of America, 2 BCS Consulting, Philadelphia, Pennsylvania, United States of America, 3 University of
the Pacific, Stockton, California, United States of America, 4 Fatigue Consultation Clinic, Salt Lake City, Utah, United States of America, 5 Center for Special Immunology,
Fountain Valley, California, United States of America, 6 Hunter-Hopkins Center, Charlotte, North Carolina, United States of America, 7 Sierra Internal Medicine Associates,
Incline Village, Nevada, United States of America, 8 Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Abstract
Background: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a severely debilitating disease of unknown
pathogenesis consisting of a variety of symptoms including severe fatigue. The objective of the study was to examine the
efficacy and safety of a TLR-3 agonist, rintatolimod (Poly I: C12U), in patients with debilitating CFS/ME.
Methods and Findings: A Phase III prospective, double-blind, randomized, placebo-controlled trial comparing twice weekly
IV rintatolimod versus placebo was conducted in 234 subjects with long-standing, debilitating CFS/ME at 12 sites. T
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