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a distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth人口不同的巨噬细胞介导转移性乳腺癌细胞外渗,建立和成长
A Distinct Macrophage Population Mediates Metastatic
Breast Cancer Cell Extravasation, Establishment and
Growth
1 1¤ 2 2 3 1 4
Binzhi Qian , Yan Deng , Jae Hong Im , Ruth J. Muschel , Yiyu Zou , Jiufeng Li , Richard A. Lang ,
Jeffrey W. Pollard1*
1 Department of Developmental and Molecular Biology and the Department of Obstetrics/Gynecology and Woman’s Health, Center for the Study of Reproductive Biology
and Woman’s Health, Albert Einstein College of Medicine, Bronx, New York, United States of America, 2 Radiation Oncology Biology, University of Oxford Churchill
Hospital, Headington, United Kingdom, 3 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America, 4 Division of
Developmental Biology, Department of Ophthalmology, The Children’s Hospital Research Foundation, Cincinnati, Ohio, United States of America
Abstract
Background: The stromal microenvironment and particularly the macrophage component of primary tumors influence their
malignant potential. However, at the metastatic site the role of these cells and their mechanism of actions for establishment
and growth of metastases remain largely unknown.
Methodology/Principal Findings: Using animal models of breast cancer metastasis, we show that a population of host
macrophages displaying a distinct phenotype is recruited to extravasating pulmonary metastatic cells regardless of species
of origin. Ablation of this macrophage population through three independent means (genetic and chemical) showed that
these macrophages are required for efficient metastatic seeding and growth. Importantly, even after metastatic growth is
established, ablation of this macrophage population inhibited subsequent growth. Furth
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