a cross-sectional characterization of insulin resistance by phenotype and insulin clamp in east asian americans with type 1 and type 2 diabetes一个横断面表征表型的胰岛素抵抗和胰岛素夹在东亚的美国人与1型和2型糖尿病.pdfVIP

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a cross-sectional characterization of insulin resistance by phenotype and insulin clamp in east asian americans with type 1 and type 2 diabetes一个横断面表征表型的胰岛素抵抗和胰岛素夹在东亚的美国人与1型和2型糖尿病.pdf

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a cross-sectional characterization of insulin resistance by phenotype and insulin clamp in east asian americans with type 1 and type 2 diabetes一个横断面表征表型的胰岛素抵抗和胰岛素夹在东亚的美国人与1型和2型糖尿病

A Cross-Sectional Characterization of Insulin Resistance by Phenotype and Insulin Clamp in East Asian Americans with Type 1 and Type 2 Diabetes 1 1 1 2 1 1 William C. Hsu *, Eyiuche Okeke , Sophia Cheung , Hillary Keenan , Tracy Tsui , Kyle Cheng , George L. King1,2 1 Asian American Diabetes Initiative, Joslin Diabetes Center, Boston, Massachusetts, United States of America, 2 Dianne Nunnally Hoppes Laboratory for Diabetes Complications, Joslin Diabetes Center, Boston, Massachusetts, United States of America Abstract Objective: Classic features of type 1 and type 2 diabetes may not apply in Asian Americans, due to shared absence of common HLA DR-DQ genotype, low prevalence of positive anti-islet antibodies and low BMI in both types of diabetes. Our objective was to characterize diabetic phenotypes in Asian Americans by clamp and clinical features. Materials/Methods: This was a cross-sectional study conducted in a referral center. Thirty East young Asian American adult volunteers (27.6 65.5 years) with type 1, type 2 diabetes or controls underwent hyperinsulinemic euglycemic clamp to assess insulin resistance and DEXA to assess adiposity. Results: Gender, BMI, waist/hip ratio, leptin, LDL, anti-GAD, anti-IA2 antibodies and C-reactive protein were similar among three groups. Serum C-peptide, adiponectin, free fatty acid, HDL concentrations and truncal fat by DEXA, were different between diabetic groups. Glucose disposal rate by clamp was lowest in type 2 diabetes, followed by type 1 diabetes and controls (5.4362.70, 7.6262.59, 8.6162.37 mg/min/kg, respectively, p = 0.001). Free fatty acid concentration universally plummeted during steady state of the clamp procedure regardless of diabetes