有哪些信誉好的足球投注网站a conserved function of c. elegans casy-1 calsyntenin in associative learning秀丽隐杆线虫的守恒函数casy-1 calsyntenin联想学习.pdfVIP
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a conserved function of c. elegans casy-1 calsyntenin in associative learning秀丽隐杆线虫的守恒函数casy-1 calsyntenin联想学习
A Conserved Function of C. elegans CASY-1 Calsyntenin in Associative Learning ´ ´ 1,2¤ 1 ¨ 1 4,5 Frederic J. Hoerndli , Michael Walser , Erika Frohli Hoier , Dominique de Quervain , Andreas 2,3 1 Papassotiropoulos , Alex Hajnal * ¨ ¨ 1 Institute of Zoology, University of Zurich, Zurich, Switzerland, 2 Division of Molecular Psychology, University of Basel, Basel, Switzerland, 3 Life Science Training Facility, ¨ ¨ Biozentrum, University of Basel, Basel, Switzerland, 4 Division of Psychiatry Research, University of Zurich, Zurich, Switzerland, 5 Center for Integrative Human Physiology, ¨ ¨ University of Zurich, Zurich, Switzerland Abstract Background: Whole-genome association studies in humans have enabled the unbiased discovery of new genes associated with human memory performance. However, such studies do not allow for a functional or causal testing of newly identified candidate genes. Since polymorphisms in Calsyntenin 2 (CLSTN2) showed a significant association with episodic memory performance in humans, we tested the C. elegans CLSTN2 ortholog CASY-1 for possible functions in the associative behavior of C. elegans. Methodology/Principal Findings: Using three different associative learning paradigms and functional rescue experiments, we show that CASY-1 plays an important role during associative learning in C. elegans. Furthermore, neuronal expression of human CLSTN2 in C. elegans rescues the learning defects of casy-1 mutants. Finally, genetic interaction stu
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