a comprehensive association analysis of homocysteine metabolic pathway genes in singaporean chinese with ischemic stroke综合协会分析,同型半胱氨酸代谢途径基因与缺血性中风在新加坡的中国.pdfVIP

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a comprehensive association analysis of homocysteine metabolic pathway genes in singaporean chinese with ischemic stroke综合协会分析,同型半胱氨酸代谢途径基因与缺血性中风在新加坡的中国.pdf

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a comprehensive association analysis of homocysteine metabolic pathway genes in singaporean chinese with ischemic stroke综合协会分析,同型半胱氨酸代谢途径基因与缺血性中风在新加坡的中国

A Comprehensive Association Analysis of Homocysteine Metabolic Pathway Genes in Singaporean Chinese with Ischemic Stroke 1 2 3,4 1 Hui-Qi Low , Christopher P. L. H. Chen , Katherine Kasiman , Anbupalam Thalamuthu , Seok-Shin 1 1 5 6 3 1 Ng , Jia-Nee Foo , Hui-Meng Chang , Meng-Cheong Wong , E-Shyong Tai , Jianjun Liu * 1 Human Genetics, Genome Institute of Singapore, Singapore, 2 Department of Pharmacology, National University of Singapore, Singapore, 3 Centre for Molecular Epidemiology, National University of Singapore, Singapore, 4 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 5 Department of Neurology, National Neuroscience Institute, Singapore, 6 Division of Medical Sciences, National Cancer Centre, Singapore Abstract Background: The effect of genetic factors, apart from 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms, on elevated plasma homocysteine levels and increasing ischemic stroke risk have not been fully elucidated. We conducted a comprehensive analysis of 25 genes involved in homocysteine metabolism to investigate association of common variants within these genes with ischemic stroke risk. Methodology/Principal Findings: The study was done in two stages. In the initial study, SNP and haplotype-based association analyses were performed using 147 tagging Single Nucleotide Polymorphisms (SNPs) in 360 stroke patients and 354 non-stroke controls of Singaporean Chinese ethnicity. Joint association analysis of significant SNPs was then performed to assess the cumulative effect of these