有哪些信誉好的足球投注网站a cluster randomized trial of routine hiv-1 viral load monitoring in zambia study design, implementation, and baseline cohort characteristics集群随机试验的常规hiv - 1病毒载量监测在赞比亚研究设计,实现,和基线人群特征.pdfVIP
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a cluster randomized trial of routine hiv-1 viral load monitoring in zambia study design, implementation, and baseline cohort characteristics集群随机试验的常规hiv - 1病毒载量监测在赞比亚研究设计,实现,和基线人群特征
A Cluster Randomized Trial of Routine HIV-1 Viral Load Monitoring in Zambia: Study Design, Implementation, and Baseline Cohort Characteristics 1,2 1 1 1 1 John R. Koethe *, Andrew O. Westfall , Dora K. Luhanga , Gina M. Clark , Jason D. Goldman , Priscilla L. 1 1 1,3 4 5 1,3 Mulenga , Ronald A. Cantrell , Benjamin H. Chi , Isaac Zulu , Michael S. Saag , Jeffrey S. A. Stringer 1 Centre for Infectious Disease Research in Zambia, Lusaka, Zambia, 2 Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 3 Department of Obstetrics and Gynecology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America, 4 Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia, 5 Division of Infectious Diseases, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America Abstract Background: The benefit of routine HIV-1 viral load (VL) monitoring of patients on antiretroviral therapy (ART) in resource- constrained settings is uncertain because of the high costs associated with the test and the limited treatment options. We designed a cluster randomized controlled trial to compare the use of routine VL testing at ART-initiation and at 3, 6, 12, and 18 months, versus our local standard of care (which uses immunological and clinical criteria to diagnose treatment failure, with discretionary VL testing when the two do not agree). Methodology: Dedicated study personnel were integrated into public-sector
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