robust control of continuous bioprocesses鲁棒控制的连续的生物过程.pdfVIP

Hindawi Publishing Corporation Mathematical Problems in Engineering Volume 2010, Article ID 627035, 18 pages doi:10.1155/2010/627035 Research Article Robust Control of Continuous Bioprocesses Gongxian Xu Department of Mathematics, Bohai University, Jinzhou 121000, China Correspondence should be addressed to Gongxian Xu, dutxugx@ Received 25 March 2010; Revised 17 May 2010; Accepted 5 July 2010 Academic Editor: John Burns Copyright q 2010 Gongxian Xu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This paper deals with robust control of continuous bioprocesses. According to the material balance equations of continuous bioprocesses, a uniform framework for mathematical modeling of this class of processes is first presented. Then a robust controller is designed by using the H∞ mixed sensitivity method for the biotechnology processes. The corresponding control objective is described as the development of a robust reference-tracking control structure with the best possible disturbance compensation, able to cope with variations in key process parameters. Finally, the proposed robust control strategy is applied to bio-dissimilation process of glycerol to 1, 3- propanediol. Simulation results are given which show that the designed robust controller makes the system have a favourable robust tracking performance. 1. Introduction The goal of bioprocess control is to optimize the performance of processes involving industrially important organisms, biomedically relevant species, and the degradation of pollutants 1. In general, a mathematical m