应用贝叶斯理论推断DNA分子标记基因型-生命科学研究.PDF

6 1 生命科学研究 Vol . 6 No . 1 2002 3 Life Science Research M ar. 2002 * DNA 莫惠栋, 姜长鉴 ( , 225009) : 引入贝叶斯理论用以从DNA 分子标记的表现型( 电泳谱带) 推断其基因型( DNA 来源) . 结果表 , 根 据标记座位独立假定而确定的遗传信息不完全标记的基因型概率, 与根据邻近的遗传信息完全标记的基因 型和有关重组率算得的相应贝叶斯概率, 通常都有很大的差异. 所以在进行数量性状基因定位和标记辅助选 择等工作之前, 应当计算每 一个体基因组上所有遗传信息不完全座位的有关基因型的贝叶斯概率. 文中列出 计算未知基因型的贝叶斯概率的详细过程, 也讨论了贝叶斯概率的若干推广应用. : 贝叶斯概率; DNA 标记; 遗传信息不完全 : Q78 : A : 1007-7847( 2002) 01- 0040-06 Inferring Genotype of DNA Molecular Marker by Bayesian Theorem MO Hu-i dong, J ANG Chang-jian ( L aboratory of Quantitat iv e Ge netics , Yangz hou University , Yangz hou 225009, Jiangsu , China) Abstract: Bayesian theorem is applied to infer the DNA molecular marker genotype(DNA chain type) from its phe- notype ( electrophoresis band type) . The results indicated that large differences often present in the genotype proba- bility of a molecular marker with incomplete genetic information when it is obtained from the assumption of indepen- dence among markers as compared with that inferred from the genotypes of the flanking markers with the complete genetic information and the recombinat ion fractions among them based on the Bayesian theorem. Therefore, before utilizing the marker information, such as in mapping quantitative trait loci ( QTL) , marker assisted selection (MAS) etc. , Bayesian probability of the genotype for all markers with incomplete geneti