2010年细菌耐药监测分析.docVIP

2010年沧州市人民医院细菌耐药监测分析 宋东平1 王 迁 2 刘红新1 从 丽1 刘俊霞1 （1．沧州市人民医院感染内科，2．沧州市人民医院感染检验科，沧州 061100） 摘要：目的 了解2010年沧州市人民医院临床分离菌对常用抗菌药物的耐药性。方法 采用纸片扩散Kirby-Bauer法,对我院2010年分离的1 465株临床分离菌株作药物敏感试验，采用WHONET 5.4统计软件对数据进行分析。结果 临床分离的细菌构成比中前3位革兰阴性杆菌分别为大肠埃希菌246株（16.8%）、肺炎克雷伯菌212株（14.5%）、铜绿假单胞菌158株（10.8%）。革兰阳性球菌中，前3位分别为金黄色葡萄球菌196株（13.4%）、凝固酶阴性葡萄球菌129株（8.8%）和肠球菌40株（2.7%）。其中MRSA的检出率为45.9%，MRCNS的检出率为52.7%，未检出万古霉素和替考拉宁耐药的革兰阳性球菌。产ESBLs大肠埃希菌和肺炎克雷伯菌的检出率分别为33.3 %（82/246）和15.1 %（32/212）肠杆科细菌对亚胺培南、美罗培南高度敏感，但鲍曼不动杆菌对亚胺培南和美罗培南的耐药率分别为33.8%和33.6%，对头孢哌酮舒巴坦的耐药率小于20%（18.5%）。铜绿假单胞菌对亚胺培南和美罗培南的耐药率均小于20%，分别为16.7%和13.6%，对头孢哌酮舒巴坦、哌拉西林钠他唑巴坦、和环丙沙星的的耐药率分别为30.3%、22.7%和52.3%。嗜麦芽窄食假单胞菌对左氧氟沙星的耐药率较低（15.4%），对磺胺甲恶唑-甲氧苄啶的耐药率33.3%。结论 2010年我院临床分离菌以革兰阴性杆菌为主，肠杆科细菌对碳青霉烯类抗生素有良好敏感。开展细菌耐药性监测，对本单位合理应用抗菌药物有重要意义。 Bacterial Drug-resistance Monitoring Analysis of Cangzhou People’s Hospital in the Year of 2010 SONG dong-ping, WANG Qian ,LIU Hong-Xin ,CONG Li ,LIU Jun-Xia (The people’ Hospital of Cangzhou ,HebeiCangzhou 061100,China0 Abstract：Objective: To realize the drug-resistant of clinical isolated bacteria against commonly used antibacterial agents of Cangzhou People’s Hospital in the year of 2010. Methods: Our hospital proceeded sensitization test by Kirby-Bauer Method on 1465 plants clinical isolated bacterial strains separated in 2010, and analyzed the data by using of WHONET 5.4 statistical software. Result:Among the constituent ratio of clinical isolated bacteria, the top three Gram Negative Bacilli (GNB) were Escherichia coli 246 strains(16.8%) , Klebsiella pneumoniae(KPN) 212 strains (14.5%), Pseudomonas aeruginosa 158 strains(10.8%). Among Positive coccus, the top three were staphylococcus aureus 196 strains (13.4%), coagulase-negative staphylococcus 129 strains (8.8%) and Enterococcus 40 strains (2.7%). The positive rate for MRSA was 45.9%, for MRCNS was 52.7%, and no resistant strain to vancomycin and teicoplanin in positive coccus was found. The positive rate for ESBLs in Escherichia coli was 33.3% (82/2