五味子藤茎对小鼠酒精性肝损伤血清转氨酶影响.docVIP

五味子藤茎对小鼠酒精性肝损伤血清转氨酶影响摘要：目的观察五味子藤茎对小鼠酒精性肝损伤血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）的影响。方法72只ICR小鼠分为6组，3个实验组给予五味子藤茎水煎液（5，10，20 g/kg)，正常对照组及模型对照组给予相同体积的生理盐水，阳性对照组给予五味子果实水煎液（10 g/kg)。除正常对照组外，其余各组动物每日灌胃56 %（V/V）白酒16 mL/kg形成肝损伤模型，10 d后检测小鼠血清中ALT、AST活性。结果五味子藤茎能显著降低肝损伤小鼠血清ALT、AST。结论五味子藤茎通过降低血清ALT、AST水平可有效防治小鼠酒精性肝损伤。 关键词：酒精性肝损伤；五味子藤茎；小鼠 中图分类号：R285文献标识码：A文章编号：1672-979X(2008)11-0053-02 Effect of Caulis of Fructus Schisandrae on Serum ALT and AST of Mice with Alcoholic Liver Injury HU Yan-wu （Department of Pharmaceutics and Food Science, Tonghua Normal College, Tonghua 134002, China） Abstract：Objective To investigate the effect of caulis of Fructus Schisandrae on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of mice with alcoholic liver injury. Methods Seventy two ICR mice were divided into 6 groups of normal control, model control, positive control and three treatment groups. The mice in treatment groups were given with the water decoction of caulis of Fructus Schisandrae (5, 10, 20 g/kg for each group), while the mice in normal control and model control groups were given with the same volume normal saline, and the mice in positive control group were treated with the water decoction of fruit of Fructus Schisandrae (10 g/kg). Then, except the mice in normal control group, all the other mice were intragastrically infused with 56 %（V/V）alcohol (16 mg/kg) to induce liver injury. After 10 days, the changes of activity of serum ALT and AST were measured. Results The caulis of Fructus Schisandrae could remarkably decrease the levels of serum ALT and AST of mice with alcoholic liver injury. Conclusion The caulis of Fructus Schisandrae can effectively prevent and cure the alcoholic liver injury in mice through reducing the levels of serum ALT and AST. Key words：alcoholic liver injury; caulis of Fructus Schisandrae; mice 五味子Schisandra chinensis(Turcz.) Baill.为木兰科植物，主产于我国东北的东部山区，其成熟果实称北五味子，是著名的长白山地道药材，具有益气生津、补肾养心、收敛固涩的作用。五味子有明显的促进肝糖元生成、降低肝炎患者血清谷丙转氨酶水