片剂（tablet）.docVIP

片剂（tablet） Concept: wetting agents are self - adhesive, but they can moisten the material in the tablet, and promote the viscosity of the material itself to facilitate granulation. An adhesive is a kind of solid powder or viscous liquid, which has the stickiness of itself and enhances the stickiness of the material without viscosity or stickiness. The dry binder is applied directly in the solid state. [medical education network collection] (three) disintegrating agent Concept: a disintegrating agent is an excipient that causes tablets to rapidly disintegrate into small particles in the gastrointestinal tract. Objective: in order to make the tablets rapidly disintegrate and give effect, tablets should be added in addition to the tablets which need to be slowly released, such as buccal tablets and long-acting tablets. 1. adding method of disintegrating agent The adding methods of disintegrating agent include addition, addition and addition. The addition method is to add the disintegrating agent to the dry particles before tabletting, and the disintegration of the tablet will occur between the particles, which is beneficial to the rapid disintegration of the tablets into granules. Addition is the addition of a disintegrating agent in the process of granulation, and the disintegration of the tablet will occur in the interior of the particle, which is conducive to the continued disintegration of the particles into fine particles. Internal and external addition is an addition part, with a part of which can cause the disintegration of the tablets both in the particles and between the particles, so as to achieve a good disintegration effect. Usually, the disintegrating dose accounted for 50% to 75% of the total amount of disintegrating agent, and the disintegrating dose accounted for 25% to 50% of the total amount of disintegrating agent. The disintegration rate and dissolution rate of the tablets were different with different adding methods of disintegrating agents. The di