选择性β1受体阻滞剂对高血压病患者β受体亚型功能的调节特性（Regulatory effects of selective beta 1 receptor blockers on beta adrenoceptor function in patients with essential hypertension）.docVIP

选择性β1受体阻滞剂对高血压病患者β受体亚型功能的调节特性（Regulatory effects of selective beta 1 receptor blockers on beta adrenoceptor function in patients with essential hypertension） Regulatory effects of selective beta 1 receptor blockers on beta adrenoceptor function in patients with essential hypertension 2011-06-15 Peng Li, Ma Shuping, Li Yulong, Yang Liming, Li Chunyan [Abstract] Objective To investigate the effects of selective beta 1 receptor blocker on the function of beta adrenoceptor subtypes in human myocardium. Methods treadmill exercise and salbutamol determination of drug trials, 20 consecutive patients underwent selective beta 1 receptor blockers in the treatment of hypertension in male patients more than 4 months, 3 days after stopping peak exercise heart rate power maximum added value (beta 1 receptor reactivity) and salbutamol (selective beta 2 receptor agonist) increased heart rate 30 beats / min when the variable dose (CD30, beta 2 receptor reactivity); 20 cases of hypertension in male patients not taking beta blockers for at least 4 months over the same period as the control to be determined. The peak exercise heart rate power maximum increment 1 selective beta blocker therapy group is 88.1 + 10.5 / min, non beta blocker therapy group (78.5 + 9.4 / min) had no significant difference (P 0.05); intravenous salbutamol CD30 selective beta 1 receptor blockers in treatment group is 1.8 + 0.3 g / kg non, beta blocker therapy group (2.7 + 0.2 g / kg) decreased significantly (P 0.001). Conclusion selective beta 1 receptor blocker has cross selectivity, which can improve the biological function of beta 2 receptor function, which may be the cytological mechanism of beta blocker withdrawal syndrome. [Keywords] hypertensive receptor, adrenergic beta 1 adrenergic beta receptor antagonist Regulative characteristics of subtypal function in patients with B -adrenoreceptor essential hypertension by chronic 1-selective antagonist Peng Yingxin beta, Ma Shuping, Li Yulong, et al. Department