硅胶表面罗红霉素分子印迹聚合物的制备及选择性吸附性能 - 化工进展.pdf

化 工 进 展 ·1162 · CHEMICAL INDUSTRY AND ENGINEERING PROGRESS 2016 年第35 卷第4 期 研究开发 硅胶表面罗红霉素分子印迹聚合物的制备及选择性吸附性能 唐志民，马新宾 （天津大学化工学院，天津 300072 ） 摘要：以γ-氨丙基三甲氧基硅烷（AMPS ）为硅胶表面改性剂，甲基丙烯酸为功能单体，乙二醇二甲基丙烯酸酯 为交联剂，罗红霉素（ROX ）为模板分子，制备得到罗红霉素分子印迹硅胶材料（ROX-MIP-PMAA/SiO2 ），采 用红外、扫描电镜和粒径测定等方法对其进行了表征。通过静态和动态吸附实验研究了 ROX-MIP-PMAA/SiO2 对罗红霉素的吸附性能，并以红霉素为竞争底物，研究其选择吸附性能。结果显示，ROX-MIP-PMAA/SiO2 对罗 红霉素的吸附能力明显大于非印迹硅胶（NIP-PMAA/SiO2 ），其对罗红霉素和红霉素的分离因子为1.21，说明其 对罗红霉素具有较好的选择吸附性能。 关键词：二氧化硅；表面；罗红霉素；表面分子印迹；吸附 中图分类号：R 927.2 文献标志码：A 文章编号：1000 –6613 （2016 ）04 –1162 –05 DOI ：10.16085/j.issn.1000-6613.2016.04.031 Preparation of roxithromycin molecularly imprinted layer-coated silica and its selective adsorption properties TANG Zhimin ，MA Xinbin （School of Chemical Engineering and Technology，Tianjin University ，Tianjin 300072，China ） Abstract ：Roxithromycin molecularly imprinted silica was prepared by using AMPS as the silica surface modifier，methacrylic acid as the functional monomer ，ethylene glycol dimethacrylate as the crosslinker，and roxithromycin as the template molecule. Its structure was characterized by infrared spectroscopy，scanning electron microscope and particle size analysis. The adsorption properties of ROX-MIP-PMAA/SiO2 on roxithromycin were studied by static binding test and dynamic binding test ， and its selective adsorption properties was investigated by selective binding test with erythromycin as the competing substrate. Results showed that the roxithromycin adsorption capacity of ROX-MIP-PMAA/SiO was better than that of NIP-PMAA/SiO . The separation factor of