ten hallmarks of cancer课件.ppt

Paper sharing:Hanahan D, Weinberg R. Hallmarks of Cancer: The Next Generation.Cell, 2011,144( 5): 646-674.;Six hallmarks of cancer proposed in 2000;Emerging hallmarks ;Sustaining Proliferative Signaling;;;;;Evading Growth Suppressors;;;Contact Inhibition;Mechanisms of Contact Inhibition ;Resisting Cell Death;Apoptosis;;Apoptosis signaling pathways ;Apoptosis-triggering mechanisms;Strategies developed by cancer cells to circumvent apoptosis;Autophagy;Autophagy is cytoprotective for cancer cells;Necrosis Has Proinflammatory and Tumor-Promoting Potential;Enabling Replicative Immortality;The telomeres, composed of multiple tandem hexanucleotide repeats, shorten progressively in nonimmortalized cells propagated in culture, eventually losing the ability to protect the ends of chromosomal DNAs from end-to-end fusions;;; Delayed Activation of Telomerase May Both Limitand Foster Neoplastic Progression;;Inducing Angiogenesis;angiogenesis;; VEGF-A; angiogenesis inhibitors;;;Activating Invasion and Metastasis;E-cadherin, a key cell-to-cell adhesion molecule;The epithelial-mesenchymal transition( EMT) Broadly Regulates Invasion and Metastasis;;;mesenchymal-epithelial transition (MET);Contributions of Stromal Cells to Invasionand Metastasis;Emerging hallmarks;Genome Instability and Mutation;;;A diverse array of defects of theDNA-maintenance machinery-caretakers of the genome;Tumor-Promoting Inflammation;;Contribution of inflammation to cancer cells;;Reprogramming Energy Metabolism;;Why cancer cells reprogram their glucose metabolism?;Evading Immune Destruction;Possible mechanisms of immunoevasion;Ten hallmarks of cancer;My gains from learning;谢谢！