Aetivin在上皮性卵巢癌中的表达及意义.pdfVIP

· 550· 中国妇幼保健2008年第23卷 Activin在上皮性卵巢癌中的表达及意义 董宇明 梁 磊 张丽敏 刘淑杰 哈尔滨医科大学附属五院(黑龙江 大庆)163316 李秀琴 中国医科大学附属二院 110001 中国图书分类号 R737．31 文献标识码 B 文章编号2008)04-0550-03 【摘 要】 目的：检测activin在上皮性卵巢癌组织中的表达，探讨activin的表达与上皮性卵巢癌临床病理特征的关系。方 法：应用免疫组织化学链霉亲和素一生物素一过氧化物霉复合物 (SABC)方法，检测40例上皮性卵巢癌组织，20例良性上皮 性卵巢肿瘤组织，20例正常卵巢组织中activin的表达情况。结果：上皮性卵巢癌组织中activin的阳性表达率为67．5％，高于良 性上皮性卵巢肿瘤组织及正常卵巢组织的25％及10％ (P0．05)，与组织学类型、临床分期无相关性 (P0．05)，与组织学分 级及淋巴结转移有关 (P0．05)。结论：Activin在上皮性卵巢癌组织中皆呈高表达，提示activin可能与上皮性卵巢癌的浸润、 转移有关。 【关键词】 Activin 上皮性卵巢癌 免疫组化 Expression of activin in epithelial ovarian cancer and its significance DONG Yu—M g，LIANG Lei．ZHANG Li—Min．et a1．Fifth Hospital Affiliated to Haerbin Medical University，Daqing 163316，Heilongjiang，China [Abstract] Objective：To study the expression of activin and its relation to histological type，grade，surgical stage and lymphatic metastasis in epithelial ovarian cancer．Methods：The expression of activin in 40 case of epithelial ovarian cancers，20 case of benign epithe- lial ovarian tumors and 20 case of normal ovarian tissues were detected by immunohistochemistry gtreptomycin—-avidin—-biotin—-peroxidase complex(SABC)method．Results：Activin was expressed 67．5％ (27／40)in epithelial ovarian cancers，25％ (5／20)in benign epithe- lial ovadan tumors and 1 0％ (2／20)in normal ovarian tissues．The expression of activin was significantly higher in epithelial ovarian cancers than that in benign epithelial ovarian tumors and normal ovarian tissues(P0．001)．The overexpression of activin 珊related to the histo- logidal grade and lymphatic metastasis，no relationship with the histological type and surgical stage(P0．05)．Conclusion：The overex- pression of activin may be related with the invasion and metastasis in epithelial ovarian cancer． [Key words] Actvin；Epithelial ovarian cancer；Immunohistochemistry 卵巢恶性肿瘤的发病率在女性生殖道癌瘤中占第3位， 同时选取同期因子宫肌瘤或子宫内膜不典型增生、子宫内膜 占生殖道恶性肿瘤