2种盐酸法舒地尔注射液对大鼠实验性脑缺血保护作用的研究.pdfVIP

2种盐酸法舒地尔注射液对大鼠实验性脑缺血保护作用的研究 傅英梅 ．廖广仁(广东省人民医院药学部，广州市 510080) 中图分类号 R965；R972；R944．1 l 文献标识码 A 文章编号 1001—0408(2008)07—0504—02 摘 要 目的：比较2种盐酸法舒地尔注射液(商品名分别为依立卢、川威)对大鼠实验性脑缺血的保护作用 、方法：SD大鼠60只 随机分为伪手术组、模型组、依立卢和川成高、低剂量组，分别给予相应药物后建立局部脑缺血模型，观察盐酸法舒地尔注射液对脑 缺血大鼠神经功能、脑梗死面积和脑组织病理形态学的影响。结果：与模型组比较，在相同剂量下，2种制剂可相同程度地降低实验 性脑缺血大鼠的神经功能评分、脑梗死面积及减轻脑组织病理形态改变(P0．05或P0．01)；2种制剂之间比较差异无显著性 (P0．05) 结论：2种盐酸法舒地尔注射液对大鼠实验性脑缺血的保护作用相当。 关键词 盐酸法舒地尔注射液；实验性脑缺血；大鼠；神经功能；保护作用 Protective Effects of Two Kinds of Fasudil Hydroehloride Injections on Experimental Cerebral Ischemia of Rats FU Ying—mei，LIAO Guang—ren(Dept．of Pharmacy，Guangdong Provincial People、s Hospital，Guangzhou 510080，China) ABSTRACT OBJECI、IVE：To compare the protective effects of two fasudil hydroehloride injections(trade name：Yililu vs． Chuanwei)on experimental cerebra1 ischemia of rats．METHODS：A total of 60 SD rats were randomly divided into sham opertion group，model group，Yililu group，Chuanwei high dose group，and Chuanwei low dose group．Cerebral ischemia model was made in each gr()up for the observation of the effects of fasudil hydroehloride injections on the neuralogical function， cerebral infarction size and the I)ath。n1()rph。1。gy of brain tissues．RESULTS：As compared with model group，two kinds of the fasudi1 hydroehloride injections at the same dose identically decreased the score of neurological function as wel1 as the cerebra1 infarction size、and lessene?d the degree of the pathomorphological change of brain tissues(P0．05 or P0．01)．However， there were no signficant differences between the two kinds of fasudil hydroehloride injections(P0．05)．CONCLUSION： The two kinds of fasudil hydroehloride injections showed an equivalent protective effect on the damage of experimental cerebral ischemia． KEY WORDS Fasudil hydroehloride injections；Experimental cerebral isehemia：Rat；Neurological function：Protective ef— fect 盐酸法舒地尔 射液是El水旭化成株式会社和名古屋大 ；水合氯醛 (天津市博迪化工有限公司，批号：