葛根素注射液的不良反应文献分析.PDF

·1150 · 现代药物与临床 Drugs Clinic 第 32 卷 第 6 期 2017 年 6 月 葛根素注射液的不良反应文献分析 霍利民，刘 莹 天津中医药大学第二附属医院，天津 300150 摘 要：目的 分析葛根素注射液所致不良反应（ADR ）的特点，为临床合理用药提供参考。方法 检索中国学术期刊（网 络版）、中国生物医学文献数据库（CBM ）、万方数字化期刊全文库、中文科技期刊全文数据库（维普）等数据库报道的葛根 素注射液致 ADR 的文献，并进行分析和讨论。结果 葛根素注射液所致 ADR 男性明显多于女性，年龄多集中在 50 岁以上； 心血管系统疾病患者的 ADR 最多，构成比为 53.6%；绝大多数患者的给药剂量为400 、500 mg/d，构成比分别为47.55% 、 26.57% ；绝大多数患者（117 例，62.23% ）给药疗程为 14 d；用药0.5～24 h 的患者最多，占21.88% ；ADR 累及器官/系统以 变态反应较为多见，构成比分别为 14.36%。结论 加强葛根素注射液 ADR 监测，确保患者临床用药安全有效。 关键词：葛根素注射液；药品不良反应；文献分析 中图分类号：R969.3 文献标志码：A 文章编号：1674 - 5515(2017)06 - 1150 - 06 DOI: 10.7501/j.issn.1674-5515.2017.06.044 Document analysis on adverse drug reaction caused by Puerarin Injection HUO Li-min, LIU Ying Second Affiliated Hospital of Tianjin University of TCM, Tianjin 300150, China Abstract: Objective To analyze the characteristics of adverse drug reactions (ADR) induced by Puerarin Injection, and to provide references for rational use in clinic. Methods China Journal Full-text Database (CNKI), Chinese biomedical literature database (CBM), Wanfang Database, Chinese Science and Technology Journal Full-text Database (VIP), etc were retrieved, and the documents of adverse drug reaction induced by Puerarin Injection were analyzed and discussed. Results Men with ADR induced by Puerarin Injection were more than women, and more were focused on above 50 years old. Patients with cardiovascular system diseases had the most ADR cases, and the constituent ratio was 53.6%. The administration dosages of most patients were 400 and 500 mg/d, respectively, accounting for 47.55% and 26.57%. Patients with course of treatment of 14 d had the highest ADR incidence. The most cases (21.88%) occured in the medication 0.5 — 24 h. Organs/systems involved by ADR mainly were allergic reaction, accounting for 14.36%. Conclusion ADR of