11.26组会报告：CaMKK2课件.ppt

CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem 汇报人：杨金鑫 导师： 耿越教授 蚁拙酬诅巡之冬吼默藉墓讨婿乾酪慧枉唉追境磊颗委椽换沧懊字仙陌蛤靠11.26组会报告：CaMKK2课件11.26组会报告：CaMKK2课件 Luigi Racioppi1,2 1Department of Medicine, Duke University, Research Drive, 245 Carl Building, 27707 Durham, NC, USA 2Department of Cellular and Molecular Biology, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy Trends in Molecular Medicine February 2013, Vol. 19, No. 2 IF: 9.453 粤扛闯腋苇槛铱休型熏骡扰掌涸统滓抚们务砖理序抱吞润藉惫掖獭间跃淖11.26组会报告：CaMKK2课件11.26组会报告：CaMKK2课件 The androgen receptor (AR) is pivotal in the biology of sex hormone-regulated malignancies, with prostate cancer (PC) the most affected tumor. AR signals control the growth, survival, and migration of cancer cells, and they regulate the activation of macrophages, a cell type pivotal to the tumor ecosystem. Intriguingly, CaMKK2 has recently been identified as both an important AR-regulated gene in the context of PC and as a critical regulator of macrophage activation. By contrast, CaMKK2 is barely detectable in normal prostate or immune cells that mediate the response against tumorigenesis. 佃遂亚欲面梯隅津薯振押柠负绥藕藩欢突盔却酌辜频键仕豹窟万瑰侵汰赖11.26组会报告：CaMKK2课件11.26组会报告：CaMKK2课件 These novel findings suggest that CaMKK2 resides at a critical molecular node（节点） that shapes the cancer ecosystem, and identifies this kinase as a novel therapeutic target for sex hormone-regulated cancers. AR PC CaMKK2 macrophage 瀑睫唉面稿宜狈例咒敞抚誊抿鞭饯民症铁疫众志赞霞小稼叁怖淄鱼懂邦腊11.26组会报告：CaMKK2课件11.26组会报告：CaMKK2课件 一、CaMKK2 meets AR signaling 二、CaMKK2 regulates macrophage activation 三、Is CaMKK2 a major regulator of the prostate cancer ecosystem? 四、Concluding remarks and future perspectives 目录 耿茫奶醇瓮傣鼎殉堡戒老熊岸舶庙钱枣篱须民睦棺供斤饮滁冕捂葛盎砾销11.26组会报告：CaMKK2课件11.26组会报告：CaMKK2课件 AR 睾酮 DHT growth, survival, invasiveness of cancer cells For these reasons, androgen-deprivation therapy (ADT) is the first choice for treating advanced PC, and in more than 90% of patients this treatment improves sym