苦瓜水提取物降血糖作用动物实验研究_胡怡秀.pdfVIP

30 　2010 1 　 17 　 1　Practical Preve tive Medici e, Ja .2010, Vol 17, No.1 :1006-3110(2010)01-0030-03 【论　著】 苦瓜水提取物降血糖作用动物实验研究 胡怡秀, 刘秀英, 马　征, 尹　进 　　:　　 II 。 　　 II , ≥8 mmol/L 2 。0.25、1.00 g/kg·bw 。30 d 、、MDA、SOD。 1.00 g/kg·bw 。 　　0.25 g/kg·bw , (P0.01), 。 1.00 g/kg·bw , MDA 。、。 。 　　II , 、。。 :　苦瓜水提取物;降血糖;动物实验研究 :R-332　　　　　:A Effect of WaterExtracts fromMomordica charantia onBlood GlucoseReductioninAnimal Experiment 　H U Y i-xiu, LI U X iu-y ing, MA Zheng, et al .(H unan Provincial Center f or Disease Control and P revention, Changsha 410005, Hunan, China ) Abstract:　Objective 　To investigate theeffect of water extracts fromMomordica charantiaon bloodglucose reduction inmicewithtype IIdiabetesmellitus.　Methods　The NIDDM modelmicewere induced by feedingwithhigh-fat diet for one month.The micewithbloodglucoseabove 8 mmo/l L wereselected and assigned intocontrol group andtwodosagegroups, the mice of thetwodosagegroups wereadministeredwithwaterextractsfromMomordicacharantia at thedosages of 0.25 g/ kg·bw and 1.00 g/kg·bw respectively.30 days later, thefasting bloodglucose, glucosetolerance, biochemical indices and serumMDA, S D were detected.Normal mice were administered with water extracts from Momordica charantia at the dosage of 1.00 g/kg·bw toobserve its bloodglucose reductioneffect.　Results　Water extracts from Momordicacharantia at the dosageof 0.25 g/kg·bw couldsignificantly reducefasting bloodglucose and raise blood glucose reduction percentage (P0.01)inhyperglycemic mice.It did not producesignificant effect ontheglucosetoleranceof hyperglycemic mice.Water extracts fromMomordica charantiaat thedosageof 1.00 g/kg·bw could significantly alleviate serumcholesterol and malondi- aldehyde inhyperglycemic mice, but further exacerbateddecreased t