基于数据挖掘的孟河名医马培之治疗痹证用药规律 - 国际中医中药杂志.pdf

国际中医中药杂志2014年2月第36卷第2期 Int J Trad Chin Med, February 2014, Vol. 36, No.2                                    ·141 ·  ·论著 · 基于数据挖掘的孟河名医马培之治疗 痹证用药规律研究 吴嘉瑞 郭位先 张晓朦 赵梦迪 黄秀勤 张冰 【摘要】 目的 基于中医传承辅助系统软件，分析孟河医家马培之治疗痹证的用药经验。方法 收 集孟河医家马培之治疗痹证的病案，采用关联规则 apriori 算法、复杂系统熵聚类等无监督数据挖掘方法， 确定处方中各种药物的使用频次及药物之间的关联规则，分析孟河医家马培之治疗痹证的用药经验。结 果 对筛选出的 61 首处方进行分析，总结出使用频次最高的前三位药物为当归、秦艽、牛膝；使用频次 最高的前三位药物组合为牛膝、当归；当归、秦艽；当归、桑枝；经过聚类算法分析挖掘出 26 个核心组 合和 13 首新处方。结论 孟河医家马培之治疗痹证经验丰富，多用祛风除湿、活血化瘀之品。中医传承 辅助系统对于挖掘名老中医临床经验具有重要价值。 【关键词】 马培之；痹证；关联规则；聚类算法 Analysis on Menghe physician Ma Peizhi’s medication rule in prescriptions for impediment syndrome based on knowledge-discovery in database Wu Jiarui, Guo Weixian, Zhang Xiaomeng, Zhao Mengdi, Huang Xiuqin, Zhang Bing. Beijing University of Chinese Medicine, 100102 Beijing ，China Corresponding author：Zhang Bing ，Email ：zhangbing6@263.net 【Abstract 】 Objective To analyze the experiences for impediment syndrome of Ma Peizhi of Menghe Medical Genre by using traditional Chinese medicine （TCM ）inheritance support system. Method The prescriptions for impediment syndrome of Ma Peizhi were collected and inputted to TCM inheritance support system, from which we can get the frequency of drug usage and the relationship between drugs based on the association rules and clustering algorithm. Results In the 61 prescriptions, the drugs that used most frequently were Chinese Angelica, Largeleaf Gentian Root, and Twotoothed Achyranthes Root, and the drug combinations that used most frequently were Largeleaf Gentian Root-Chinese Angelica, Chinese Angelica-Largeleaf Gentian Root, Chinese Angelica-Mulberry Twig. And there were also 26 core combinations and 13 new prescriptions mined from the database. Conclusion Ma Peizhi of Menghe Medical Genre was well experienced imp