介孔二氧化硅纳米粒传递肿瘤诊疗药物的研究进展 - 药学学报.pdf

8 药学学报 Acta Pharmaceutica Sinica 2013, 48 ( 1) : 8 13 介孔二氧化硅纳米粒传递肿瘤诊疗药物的研究进展 1 1 2 1* 昕 , 滕兆刚 , 黄小银 , 卢光明 (南京军区南京总医院 1. 医学影像科, 2. 肿瘤科, 江苏 南京 210002) 摘要: 介孔二氧化硅纳米粒 (mesoporous silica nanoparticles, MSNs) 作为药物载体应用于生物医药领域已 成为纳米药剂研究的热点。本文针对在肿瘤诊疗领域的MSNs 必威体育精装版实验设计, 重点讨论MSNs 载药系统在控制 性释放、靶向性输送和克服多药耐药的应用策略。MSNs 为肿瘤诊疗药物的传递提供良好的运载平台, 具有极大 的发 潜力和独特优势。 关键词: 二氧化硅; 纳米粒; 药物载体; 肿瘤 中图分类号: R943 文献标识码:A 文章编号: 05 13-4870 (2013) 01-0008-06 Mesoporous silica nanoparticles for cancer theranostic drug delivery 1 1 2 1* WANG Xin , TENG Zhao-gang , HUANG Xiao-yin , LU Guang-ming (1. Dep artment of Radiology, 2. Dep artment of Oncology, Jinling Hosp ital, Nanj ing 210002, China) Abstract: Mesoporous silica nanoparticles as drug carrier have become the new hot point in the field of biomedical application in recent years. This review focuses on the more recent developments and achievements on experimental design aspect of mesoporous silica nanoparticles with cancer diagnosis and therapy. The key advances of functionalization strategies of mesoporous silica nanoparticles with controlled release, tumor targeting and overcoming multidrug resistance are discussed in particular. Mesoporous silica nanoparticles as unique delivery systems have the potential to provide significantly a sound platform for cancer theranostic application . Key words: silicon dioxide; nanoparticle; drug carrier; carcinoma 自 1992 年 Mobil 公司首次合