2005微循环阻力与无复流.pdf

C 2007, the Authors Journal compilation C 2007, Blackwell Publishing, Inc. DOI: 10.1111/j.1540-8183.2007.00274.x CORONARY PHYSIOLOGY Relationship between Microvascular Resistance and Perfusion in Patients with Reperfused Acute Myocardial Infarction MURAT SEZER, M.D., BERRIN UMMAN, M.D., IREM OKCULAR, M.D., YILMAZ NISANCI, M.D., and SABAHATTIN UMMAN, M.D. From the Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey Despite its prognostic importance, accurate assessment of microvascular perfusion in patients with ST elevation acute myocardial infarction (STEMI) is difficult. As a new tool, the index of microvascular resistance (IMR) measurement provides us a new opportunity for interrogating microvascular condition after STEMI. In this study, we measured IMR in infarct-related artery (IRA) and explored its relation with other indices which have been suggested to evaluate microvascular perfusion in patients with reperfused STEMI. Methods: Forty-two patients with STEMI treated successfully with primary percutaneous coronary intervention (pPCI) were prospectively included. After 48 hours following pPCI, patients were recatheterized and IMR, coronary flow reserve (CFR), systolic and mean coronary wedge pressures (CWPs and CWPm) pressure-derived collateral flow index (CFIp) were measured in IRA by using intracoronary pressure-temperatur