艾司西酞普兰与舍曲林治疗重度抑郁症疗效比较.docVIP

艾司西酞普兰与舍曲林治疗重度抑郁症疗效比较 李华荣 (聊城市第四人民医院,山东 聊城 252000) [关键词] 抗抑郁药;艾司西酞普兰；重度抑郁症;舍曲林; [摘要]目的 比较艾司西酞普兰与舍曲林对重度抑郁症的疗效及安全性。方法 125例抑郁症分为2组。艾司西酞普兰组63例[男性30例，女性33例，年龄（36±12）岁，本次抑郁症期（3±4）mo]给予艾司西酞普兰10~20 mg,po, qd; 舍曲林组62例[男性28例，女性34例，年龄（40±11）岁，本次抑郁症期（3±4）mo]给予舍曲林50～100 mg,po,qd;均6 wk为一个疗程。结果 对抑郁症状的治疗，艾司西酞普兰组显效率为71%，舍曲林组显效率74%，2组疗效比较差异无显著意义（P＞0.05）；对伴随焦虑症状的治疗，艾司西酞普兰组显效率48%，舍曲林组显效率45%，2组疗效比较差异无显著意义（P＞0.05）。药物不良反应发生率2组相当。结论 艾司西酞普兰与舍曲林疗效相当，能有效治疗重度抑郁症及伴随焦虑症状，不良反应轻微。 [中图分类号]R971.4 [文献标识码] Comparative study of escitalopram and sertraline in Severe depression disorder LI Hua-rong (The Fouth peooles Hospital of Liaocheng Municipal,Liaocheng SHAN-DONG 252000,China) [KEY WORDS] antidepressive agents; escitalopram; Severe depression ;sertraline [ABSTRACT] AIM Esmolol comparison of escitalopram and sertraline for severe depression, the efficacy and safety.METHODS 125 cases of depression were divided into 2 groups. escitalopram group of 63 patients [male 30 cases, female 33 cases, age (36 ± 12) years of age, this depression period (3 ± 4) mo] to give escitalopram 10 ～ 20mg , po,qd; sertraline group of 62 cases [28 cases of male, female 34 cases, age (40 ± 11) years of age, this depression period (3 ± 4) mo] given sertraline 50～ 100 mg, po , qd; are 6wk as a course of treatment.RESULTS Symptoms of depression treatment, escitalopram group were 71% efficiency, the efficiency of sertraline group were 74%, Group 2 efficacy was no significant difference (P 0.05); pairs of anxiety symptoms associated with the treatment, escitalopram group were 48% efficiency, the efficiency of sertraline group were 45% efficacy difference between two groups was not significant (P 0.05). The incidence of adverse drug reaction rather two groups.CONCLUSION escitalopram and sertraline efficacy equivalent to the effective treatment of severe depression and anxiety symptoms associated with mild adverse reactions. 艾司西酞普兰为选择性5-羟色胺再摄取抑制（SSRI），旋对映体5-HT转动体异构位点亲和力高，增加了与基本结合位点的结合时间与强度，增强了5-HT再摄取的抑制，其作用为西酞普