免疫组化的临床意义（Clinical significance of immunohistochemistry）.docVIP

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免疫组化的临床意义（Clinical significance of immunohistochemistry）.doc

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免疫组化的临床意义（Clinical significance of immunohistochemistry）

免疫组化的临床意义（Clinical significance of immunohistochemistry） Clinical significance of commonly used immunohistochemical markers In clinical pathology, we used tumor cell immunohistochemistry prognosis resistance marker , but many units only write positive results, do not write the results of clinical significance, clinical little help, because many doctors do not understand the significance of these results, it is recommended that you in such a report, the group of tumor cell immunity the resistance of the significance of prognostic markers in print in the report, in order to increase the use value of the pathological report. 1. The prognostic markers of immunohistochemistry for malignant tumors are complete set of 4 items: P-gP, GST, PI, TOPO, II, Ki-67. 2, breast cancer, immunohistochemical resistance, prognostic markers, a total of 7 items: P-gp, GST, PI, TOPO II, Ki-67, ER, PR, C-erbB-2. 3, meaning: markers - role - positive parts - clinical significance Multidrug resistance gene protein (P-Gp) - drug pump - cell membrane / cytoplasm, positive rate is higher, the stronger the following drug resistance: doxorubicin, epirubicin, daunorubicin, mitoxantrone, vincristine, Changchun methylcytisine, paclitaxel, docetaxel. Glutathione S transferase (GST PI) - detoxification - cytoplasm - the higher the positive rate, the stronger resistance to the following drugs: adriamycin, cisplatin, nitrogen mustard, cyclophosphamide, tumor ning. Topoisomerase II (TOPO II) - positive rate target -- the nucleus -- the higher the more effective of the following drugs: anthracyclines and podophyllotoxins, such as VP16, teniposide, ellipticine, neomycin, daunorubicin, doxorubicin, epirubicin, VM26. Those with high positive rates are particularly effective for VP16. Estrogen receptor (ER) - sex hormone - the nucleus - the higher the positive rate, the more effective the endocrine therapy is, the better the prognosis is. Progesterone receptor (PR) - sex hormone - the nucleus - the higher the