补元通络汤治疗肾虚痰瘀阻滞型肺癌骨转移的临床探究.pdfVIP

提 要 目的：观察补元通络汤联用唑来膦酸注射液治疗肾虚痰瘀阻滞型肺癌骨转移的临 床疗效并探讨其机理。方法：将40例肺癌骨转移患者随机分为治疗组和对照组，每组 各20例。治疗组给予口服补元通络汤联合静脉应用唑来膦酸注射液；对照组予单纯唑 来膦酸注射液静脉点滴。观察两组患者治疗前后的临床症状、生活质量、血CEA、血 沉、血T细胞亚群、外周血象变化情况及副作用。结果：补元通络汤联用唑来膦酸注 射液治疗可以明显的改善临床症状，提高患者生存质量，降低发热、乏力及胃肠道反 应等症状，疗效明显优于单纯静脉应用唑来膦酸注射液组。结论：补元通络汤联用唑 来膦酸注射液治疗肺癌骨转移有较明显的临床疗效，但由于观察时间短，对于生存期 及效果持续时间的情况，有待于进一步的观察研究。 关键词 补元通络汤；肾虚痰瘀阻滞型；肺癌骨转移；临床研究 The Clinical Study of Buyuan Tongluo Tang in Treating Bone Metastasis From Lung Cancer with Kidney Deficiency and Blood Stasis Form Special: Internal Medicine of Integrated TCM and Western Student:li yulin Tutor: Prof. Tang youjun Abstract Objective: To investigate the hemostasis of Buyuan Tongluo Tang in treating kidney deficiency and blood stasis type bone metastasis from lung cancer and to explore its mechanism. Methods: 40 cases of bone metastasis from lung cancer patients were randomly divided into two groups, one group of 20 cases, to consolidate Buyuan Tongluo recipe plus receiving intravenous infusion of zoledronic acid, the control group of 20 cases, to receive intravenous infusion of zoledronic acid alone. Before and after treatment were observed in patients with the clinical symptoms, quality of life, as changes in the peripheral blood toxicity and the emergence of the situation. Results: The combination of traditional Chinese and western medicine treatment can significantly improve symptoms, improve quality of life, reduce the side effects of chemotherapy, reducing infection rates, effective than chemotherapy alone group. Conclusion:Integrated Treatment of bone metastasis from lung cancer have a more pronounced clinical effect, but the result of the short time period