miR-21的高表达与肺癌预后关系的meta分析.pdfVIP

郭仲莉等：miR-21 的高表达与肺癌预后关系的meta 分析 58 《激光杂志》2014 年第35卷第1 期 LASERNAL(Vol.35.No.1.2014) miR-21 的高表达与肺癌预后关系的meta 分析 郭仲莉，曾照芳 （重庆医科大学检验医学院，临床检验诊断学教育部重点实验室，重庆 400016） 摘要：目的：评价miR-21 的高表达与肺癌预后的相关性。方法：检索PubMed,EMBASE,Google scholar ，维普，CNKI 等数据库，收集已公开发表的关于miR-21 的高表达与肺癌预后相关性的文献，按meta 分析的要求对原始文献的质量 进行评估, 采用STATA V12.0 软件对各研究的效应量进行统计分析。结果：共纳入7 篇文献（共369 个病例），总生存率 (OS)HR 的合并值为1.34(95%CI ：1.19 至1.50 ，P 0.05) 。结论：miR-21 的高表达是肺癌预后的一个危险因素。 关键词：meta 分析；肺癌；miR-21 ；高表达 中图分类号：TN244.8 文献标识码：A 文章编号：0253-2743 （2014 ）01-0058-02 Significance of high miR-21 expression on the prognosis of lung carcinoma:A meta-analysis Guo Zhong-li ，Zeng Zhao-fang (Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education Chongqing Medical University Chongqing 400016, China) Abstract: Objective To evaluate the correlation between the high expression of miR-21 and the prognosis of lung cancer. Methods ：Eligible studies which studied the correlation between the high expression of miR-21 and the prognosis of lung cancer were collected through searching PubMed,EMBASE, and Google scholar ，VIP ，CNKI databases, etc. A meta analysis method was used to use stata v12.0 software to evaluate whether the high expression of miR-21 has an association with the prognosis of lung cancer. Results ：A total of 7 studies (369 cases) were involved in this meta-analysis. For overall survival (OS),the pooled hazard ratio (HR) of higher miR-21 expression in cancerous tissues was 1.34(95%CI: 1.19 ～1.50 ，P0.05). Conclusions: High expression of miR-21 is a risk factor of lung cancer. Key words: Meta analysis ；lung cancer ；miR-21 ；high expression 肺癌是常见的恶性肿瘤之一，近几年逐步发展为发 1.2