PDGFA在甲状腺乳头状癌中表达及意义.docVIP

PDGFA在甲状腺乳头状癌中表达及意义【摘要】 目的 探讨PDGFA在甲状腺乳头状癌组织中的表达及其意义。方法 免疫组织化学染色检测甲状腺乳头状癌组织和正常的甲状腺组织中PDGFA的表达差异。结果 甲状腺乳头状癌病例组(HSCORE中位数=1.92,SEM=0.46)与正常甲状腺组(HSCORE中位数0.38,SEM=0.05)PDGFA链的表达有显著差异,P 图1 PDGFA在甲状腺乳头状癌中的阳性表达(200×) 图2 PDGFA在甲状腺乳头状癌中的阳性表达(400×) 图3 正常甲状腺组织中PDGFA的弱阳性表达(200×) 图4 正常甲状腺组织中PDGFA的弱阳性表达(200×) 参考文献 [1] Matsuo K,Tang SH,Sharifi B.Growth factor production by human thyroid carcinoma cells:abundant expression of a plateletderived growth factorBlike protein by a human papillary carcinoma cell line.J Clin Endocrinol Metab,1993,77(4):9961004. [2] Lessey BA,Castelbaum AJ,Sawin SW,et al.Aberrant integrin expression in the endometrium of women with endometriosis.J Clin Endocrinol Metab,1994,79:643649. [3] Harrington DJ,Lessey BA,Rai V,Bergqvist A,Kennedy S,Manek S,Barlow DH,Mardon HJ.Tenascin is differentially expressed in endometrium and endometriosis.J Pathol,1999,187(2):242248. [4] Hermanson M,Funa K,Hartman M,et al.Plateletderived growth factor and its receptors in human glioma tissue:expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.Cancer Res,1992,52(11) [5] Tallquist M,Kazlauskas A.PDGF signaling in cells and mice.Cytokine Growth Factor Rev,2004,15(4):205213. [6] 刘中砚,杨镇.周细胞与微血管相关疾病.微循环学杂志,2005,15(3):5557. [7] Anan K,Morisaki T,Katano M,et al.Vascular endothelial growth factor and plateletderived growth factor are potential angiogenic and metastatic factors in human breast cancer.Surgery,1996,119(3):333339. [8] Betsholtz C,Lindblom P,Bjarnegard M,Enge M,et al.Role of plateletderived growth factor in mesangium development and vasculopathies:lessons from plateletderived growth factor and plateletderived growth factor receptor mutations in mice.Curr Opin Nephrol Hypertens,2004,13(1):4552.Review. [9] Pietras K,Rubin K,Sjoblom T,et al.Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.Cancer Res,2002,62(19):547684. [