trpv4通道与脑缺血再灌注损伤的研究进展 - semantic scholar.pdfVIP

生理学报Acta Physiologica Sinica , October 25, 2015, 67(5): 527–532 527 DOI: 10.13294/j.aps.2015.0065 综　述 TRPV4通道与脑缺血再灌注损伤的研究进展 1 1 1 1 1 2,* 丁浩 ，林叶昕，沈绮雯，潘智 ，王振超，陈蕾 12012 4 2 210029 南京医科大学 年级七年制临床医学系 班；生理学系，南京 4 (transient receptor potential vanilloid 4 channel TRPV4 ) 摘 要：香草素受体 型瞬时感受器电位通道 ， 通道 是瞬时感受器电位通 道家族成员之一。TRPV4通道是一种对钙离子具有选择通透性的阳离子通道，该通道激活后可以引起胞内钙离子浓度升 高，进而参与调节机体多种生理或病理过程。现已证明，TRPV4通道可能在脑缺血再灌注所致的神经损伤中发挥重要作 用。本文对近年来有关TRPV4通道与脑缺血再灌注损伤方面的研究进展予以综述。 关键词：TRPV4通道；钙离子；脑缺血再灌注 中图分类号：R743.3 Research progress of TRPV4 and cerebral ischemic reperfusion injury 1 1 1 1 1 2,* DING Hao , LIN Ye-Xin , SHEN Qi-Wen , PAN Zhi , WANG Zhen-Chao , CHEN Lei 1Class 4 Grade 2012, Seven-year Program of Clinical Medicine; 2Department of Physiology, Nanjing Medical University, Nanjing 210029, China Abstract: Transient receptor potential vanilloid 4 (TRPV4) channel is a member of transient receptor potential superfamily. TRPV4 is selectively permeable to calcium. Activation of the TRPV4 channel induces an increase in intracellular calcium concentration and plays an important role under physiological and pathological conditions. Especially, there is evidence showing that TRPV4 is involved in cerebral ischemic reperfusion injury. The present paper reviewed some research progress about the role of TRPV4 in cerebral ischemic reperfusion injury. Key words: transient receptor potential vanilloid 4 channel; calcium; cerebral ischemic reperfusion 1 TRPV4通道与TRP家族 白质组成了数量庞大、种类繁多的TRP 通道超家族， [1–4] TRP