iron deficiency anemia （缺铁性贫血）.pptVIP

Iron Deficiency Anemia （缺铁性贫血） 瑞金医院血液科 Normal iron physiology Question ? Total body iron? 4 g 40 g 400 g Important Fe-containing compounds in the human The body’s iron economy Definition History Anemia:male120g/l,female110g/l Caused by lack of iron Medieval times “chlorosis”, a term derived from Greek word meaning “green” “green sickness” greenish pallor as a prominent manifestation 1）Stage 1: Iron depletion (铁耗减阶段） storage iron is decreased or absent serum iron concentration and blood hemoglobin levels are normal 2）Stage 2: Iron deficient erythropoiesis (红细胞内铁缺乏阶段） storage iron is decreased or absent low serum iron concentration and transferrin saturation, without frank anemia 3）Stage 3: Iron deficiency anemia （缺铁性贫血阶段） storage iron is decreased or absent low serum iron concentration and transferrin saturation low hemoglobin level and hematocrit value hypochromic microcytic erythrocytes Prevalence The incidence of IDA in USA 1% adult men younger than 50 years of age 2-4% adult men older than 50 years of age 9-11% in menstruating women 1-7% postmenopausal women Particularly common in infants (6-20 months) and pregnant women The incidence of IDA in Shanghai Etiology and Pathogenesis Etiology Insufficient iron in the diet and periods of rapid growth Poor absorption of iron by the body Ongoing blood loss, most commonly from menstruation or from gradual blood loss in the intestinal tract Insufficient iron in the diet and periods of rapid growth Infants, children, and adolescents in rapid growth phases Infants - cow’s milk, prematurity and low birth weight 1-3 years old children - cow’s milk and low iron food adolescents - more growth occurs, menstrual blood loss Pregnant or lactating women having an increased requirement for iron Fetus for erythropoiesis, blood loss at delivery, and lactation - 900mg iron-deficiency mothers are likely to have babies with low iron reserves Malabsorption Atrophic gastritis （萎缩性胃炎） Achlorhy