research progress of skin-derived precursor - 南方医科大学学报.pdf

·420 · doi 10.3969/j.issn. 1673-4254.2017.03.26 J South Med Univ, 2017, 37(3): 420-422 综述 皮肤源性前体细胞的研究进展皮肤源性前体细胞的研究进展 1，2 1 1 陈若思 ，苗 勇 ，胡志奇 1 2 南方医科大学南方医院，广东 广州 510515；约翰·霍普金斯大学医学院，马里兰州巴尔的摩市 摘要：皮肤源性前体细胞（SKPs）是一种能从胚胎及成年真皮中提取的神经嵴来源的新的前体细胞，因其具有来源丰富、易于获 取、具有多向分化潜能、无伦理限制等优点，在疾病治疗等方面均具有重要的研究意义和良好的应用前景。本文就SKPs 的来 源、定位、增殖与分化等对其研究进展作一综述。SKPs来源于胚胎神经嵴，但不同部位的SKPs来源亦略有不同。SKPs广泛存 在于皮肤真皮中，DP 是SKPs 的一个富集龛，真皮层内的毛细血管周即是SKPs 的另一富集龛，但关于SKPs体内富集龛位置的 确定，仍需进一步的探索。SKPs可行自体移植并具有多向分化潜能，在机体多种组织修复和疾病治疗中有着重要的研究价值。 关键词：皮肤源性前体细胞；成体干细胞；组织工程；毛发再生 Research progress of skin-derived precursor cells 1, 2 1 1 CHEN Ruosi , MIAO Yong , HU Zhiqi 1Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Medical College ，The Johns Hopkins University, Baltimore, United States of America Abstract: As a novel population of neural crest-origin precursor cells, skin-derived precursor cells (SKPs) can be isolated from both embryonic and adult dermis. These cells have important values for research and potential clinical application in wound healing, organ regeneration and disease treatment for advantages in the abundance of cell sources, accessibility, potential of multipotent differentiation, and absence of ethical concerns. Here we review the developmental and anatomical origins of SKPs and their potential application in regenerative medicine. SKPs originate from the embryonic neural crest, and their sources may vary in different areas of the body. SKPs are widely found in the dermis, especially in the dermal papilla (DP), which was known as a niche of SKPs. The multipotent SKPs can used for autologous transplantation and are of vital importance in tissue repair. Keywords: skin-derived precursor cells; adult stem cell; tissue engineering; hair regeneratio