肿瘤固有免疫的新靶点：唾液酸结合的免疫球蛋白 - 中华临床医师杂志.pdfVIP

中华临床医师杂志( 电子版)2016 年5 月第10 卷第9 期 Chin J Clinicians(Electronic Edition),May 1,2016,Vol.10,No.9 ²1303 ² ²综述² 肿瘤固有免疫的新靶点：唾液酸结合的免疫球蛋白样 凝集素（Siglec）-7/9 1 1 1 2 1,3,4 陈子 柏芳芳 黄茂 朱进 周林福 【摘要】 固有免疫参与形成抗肿瘤的第一道防线，并在肿瘤免疫过程中发挥重要作用。但是， 固有免疫非但不能清除肿瘤细胞，反而会引起抑癌作用下降，甚至转变成促进肿瘤生长的帮凶，具 体机制尚无定论。近年来研究发现，唾液酸结合的免疫球蛋白样凝集素 （sialic acid-binding immunoglobulin-like lectin，Siglec）-7/9 参与调节肿瘤固有免疫，可能是未来肿瘤患者免疫治疗的新 靶点。本文将就肿瘤免疫编辑学说、固有免疫细胞与肿瘤免疫的联系以及Siglec-7/9 在肿瘤免疫中的 作用作一综述。 【关键词】 肿瘤免疫编辑； Siglec-7/9； 杀伤细胞，天然； 吞噬细胞 A new target for tumor innate immunity: sialic acid-binding immunoglobulin-like lectin (Siglec)-7/9 1 1 1 2 1,3,4 1 Chen Zi , Bai Fangfang , Huang Mao , Zhu Jin , Zhou Linfu . Department of Respiratory Medicine, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China; 2Military Medical Institute of Nanjing Command, Nanjing 210002, China; 3Lab of Respirology, Institute of Integrative Medicine, Nanjing Medical University, Nanjing 210029, China; 4Department of Respiratory Medicine, Jiangsu Shengze Hospital Jiangsu Province Hospital at Shengze, Suzhou 215228, China Corresponding author: Zhou Linfu, Email: lfzhou@njmu.edu.cn 【Abstract 】 Innate immunity constitutes the first line of defense against tumor, which plays an important role in tumor immunity. However, it does not destroy tumor cells but decreases the inhibitory effect and even promotes tumor growth, irrespective of the uncertain mechanism. Recent studies have shown that sialic acid-binding immunoglobulin-like lectin (Siglec)-7/9 is involved in the regulation of tumor innate immunity, which may become a new target for future immunotherapy of p