抗肿瘤药物研究新靶点及研究进展——极光激酶和Pin1 - 药学学报.PDF

264 药学学报 Acta Pharmaceutica Sinica 2009, 44 (3) : 264269 抗肿瘤药物研究新靶点及研究进展 ——极光激酶和Pin1 * 陈晓光, 张 翼 (中国医学科学院、北京协和医学院药物研究所, 北京 100050) 摘要: 恶性肿瘤是威胁人类生命健康的重大难治性疾病，人类在恶性肿瘤的治疗过程中经历了漫长的历史变 迁。抗肿瘤药物是重要的治疗手段之一，随着研究的深入与科学技术的发展，抗肿瘤药物随着新靶点的发现而 不断进步。大量新的抗肿瘤药物靶点如极光激酶和Pin1 的发现以及它们与肿瘤发生发展关系的阐明为寻找有效 的抗肿瘤药物，更好地治疗肿瘤奠定了基础，目前已经有针对新靶点的药物进入临床前或临床研究。 关键词: 恶性肿瘤; 药物新靶点; 极光激酶; Pin 1 中图分类号: R963 文献标识码:A 文章编号: 05 13-4870 (2009) 03-0264-06 Recent advance in the study of novel anti-tumor targets and drugs aurora kinase and Pin1 * CHEN Xiao-guang , ZHANG Yi (Institute of Materia Medica, Chinese Academy of M edical Sciences and Peking Union M edical College, Beij ing 100050, China) Abstract: Malignant tumor, one of the most refractory diseases, plays a threaten role in human health, the therapy and research on malignant tumor have taken a long way to go. The anti-tumor drugs which are the essential therapy strategies upgrade with the development of new anti-tumor targets and the research on tumor pathogenesis. Aurora kinase and Pin1, the novel anti-tumor targets, maintain the important relationship with tumor. Many new compounds designed on these targets have excellent anti-tumor effects and also enter into phase Ⅰor phase Ⅱ clinical trial. Key words: malignant tumor; drug new target; aurora kinase; Pin1 据美国国立卫生研究院 (National Institutes of 历程，提出了许多理论和学说。肿瘤研究经历了 20 Health, NIH) 2007 年的数据显示，心血管疾病、恶性 世 70 年代的癌基因时代, 80 年代的抑癌基因时代, 肿瘤和脑血管疾病是导致人类死亡的前三位致命性