蚓激酶肠溶片联用马来酸桂哌齐特治疗急性脑梗死的疗效观察.pdfVIP

蚓激酶肠溶片联用马来酸桂哌齐特治疗急性脑梗死的疗效观察 刘光勇 冯燕红 阳春市人民医院内科 广东阳春 529600 摘 要 目的 观察蚓激酶肠溶片联用马来酸桂哌齐特治疗急性脑梗死的临床疗效。方法 将8 3例急性 脑梗死患者随机分成两组，治疗组(4 2例)口服蚓激酶肠溶片2粒，t i d，同时给予马来酸桂哌齐特注射液 24 Omg O．9％生理盐水2 5 Om1 ivdri P qd×2l，对照组给予复方丹参注射液2 Om1+O．9％生理盐水2 5 Om1 i vdri P q d×2l，分别观察两组临床疗效及实验室指标的变化。结果 治疗组总有效率为8 8．1％，对照 组为5 8．5％，差异有显著性意义 (PO．O1)。治疗后实验室指标血粘度和纤维蛋白原等均降低，明显优 于对照组 (PO．O1)。两组无明显不良反应。结论 应用蚓激酶肠溶片联用马来酸桂哌齐特治疗急性脑 梗死有较好疗效 关键词 蚓激酶 肠溶片 马来酸桂哌齐特 急性脑梗死。 Obse rvat i on of I umbrok i nase d i SC j 0 i ned C i nepaz i de ma I eate i nj ec— t i on i n t r eat i ng acute ce r eb r a nfa rct i on LIU Guang——yong FENG Yang——hong Department of Internal Medi caine，The Peopl e’S Hospi tal of Yangchun，Yangchun 529600 Guangdong China Abst ract Objective To eva1uate the treating effeCt 0f 1umbrokinase j0ined Cinepazlde maleate injection in treating patients with acute cerebral infarction(ACI)．Methods 83 cases ACI patientS were randomlY divided into two groups．In treatment group，42 patientS were given hmbrokinase diSC：2pcS，tid X 2l，and alSO the Cinepazide maleate injection 240mg+0．9％NS 250mi ivdrip， qd X 21．And in control group，the patients were given compositae radix salviae mi 1tiorrhizae injection 20ml+0．9％NS 250mi ivdrip qd X 21．Then observed the treating effi— cacy and the changes of the laboratory targets．Results There were Significant differences (88．1％VS 58．5％P0．01)in the total efficiency between treatment group and control group． After the treating， the laboratory targetS、blood viSCOSitY and fibrinogen decreased， which were superior the contro1 group(P0．01)．There were no obvious bad reactions in the two group．Conclusion Lumbrokinase j0ined Cinepazide maleate injection iS effective in treating ACI． Key words Lumbrokinase Cinepazide Maleate Injection Acute Cerebral Infarction(ACI) 中图分类号：R74 3．3 3；R4 5 3 文献标识码：A 文章编号：l 0 0 7一l 24 5(2 0 0 8)l 5-0 0 7 3—03 脑梗死的致残率严重影响人类健康和生存，恢复或 诊，无严重心肺肝肾等重要疾病。随机选取8 3例， 改善脑缺血组织的灌注成为急性脑梗死治疗的主要临床手