本科毕业论文--有机合成.docVIP

[摘要]　世界各国对环保的越来越重视，这使得农药开发正朝着高效、低毒、安全性残留期短的方向发展。本文采用活性基团拼接的方法，将具有较好活性的基团芳氧乙酰基及氨基噻二唑基引入到硫脲类化合物中,具体步骤是从芳酚出发，先于氯乙酸反应，生成芳氧乙酸，在无水的条件下与二氯亚砜作用得到芳氧乙酰氯，然后立即在无水条件下与硫氰酸钾反应，生成芳氧乙酰基异硫氰酸酯，最后再与5-甲基-2-氨基-1，3，4-噻二唑反应合成了2个未见文献报道含杂环的芳氧乙酰基硫脲类化合物，以期发现更高效广谱低毒并具备更多优点的新颖结构的新型含杂环的芳氧乙酰基硫脲衍生物的先导体化合物，进而能够更深入地研究开发出农药新品种。2个新化合物通过IR对所合成的新化合物进行了结构确认和表征。该实验方法简单,时间短,产率高,具有很高的理论和实际应用价值。 [关键词]：芳氧乙酰基 硫脲 噻二唑 酰氯 异硫氰酸酯 合成 Synthesis and studies of N-aryloxyacetyl - N `- [5 - methyl-1 ,3,4 - thiadiazole -2 - yl] thiourea Student: College of Chemistry and Environmental Engineering Teacher: College of Chemistry and Environmental Engineering Abstract: The worlds increasing emphasis on environmental protection, which makes pesticides are moving towards the development of high efficiency, low toxicity, the safety of residues in the direction of a short period. In this article, using active groups splicing method,Will have a better activity of the group aryloxyacetyl and-thiadiazole-introduced to the thiourea compounds, concrete steps from the starting-phenol first react with chloroactic acid to give the oxygen-generating acid ,then react with thionyl chloride to give aryl-oxygen-acetyl chloride under the conditions of free-water ,and then react with potassium thiocyanate immediately under the conditions of free-water to generate aryloxyacetyl isothiocyanate, with the final 5 - methyl-2 - amino-1 ,3,4 - thiadiazole reaction of the two heterocyclic not reported in the literature of the aryloxyacetyl thiourea compounds, With a view to find more efficient and have low toxicity broad-spectrum advantage of the more innovative new structure with the heterocyclic aryloxyacetyl thiourea derivatives of the precursor compound, then to more in-depth research to develop new varieties of pesticides.Two new compounds by IR on the structure and characterization confirmed.This method has high theoretical and practical valne with simply,reduced time and high ratio. Keywords: aryloxyacetyl thiourea thiodiaz