对锑浸出量测定法修订的建议.pdfVIP

中国医药工业杂志 Chinese Joumal of Phannaceuticals 2015 , 46 (1 0) • 1117 • 对锦浸出量测定法修订的建议 严相平l ，张佳楠l ，2 ，侯红存3 (1 南京工业大学江苏省药物研究所，江苏南京 210009; 2. 南京工业大学药学院，江苏南京 211816; 3 石药银湖制药有限公司，山西运城 044000) 摘要:发现了现有国家标准锦浸出量的测定方法存在系统误差。基于试验原理，探讨了误差产生的原因，并对现有国家标准方 法进行了适当改进，如保证样品与对照品测定体系中的盐酸浓度相同，且样品与对照品的反应体积→致。修订后的方法可用于 锐的测定。 关键词:锦:浸出量:比色法:测定 中图分类号: R917 文献标志码:A 文章编号: 1001-8255(2015) 10-1117-02 001: 10.16522/ki.cjph.20 15.10.0 17 Recommendations of Determination Method for the Leaching Amount ofAntimony l 3 YAN Xiangping\ ZHANG Jianan ,2 , HOU Hongcun (1. Jiangsu Provinciallnstitute ofMaterial Medica , Nanjing University ofTechnology. Nanjing 210009; 2. School o{Pharmaceutical Sciences, Nanjing Uniνersity oj:陀chnology， Nanjing 211816; 3. Shiyao Yinhu Pharmaceutícal Co., Ltd., Yuncheng 044000) ABSTRACT: Some systematic eηors were found in the current standard determination method for the leaching amount of antimony. The cause of the systematic error was discussed based on the experimental principle. Some recommendations were made , for example , to assure the concentrations of hydrochloric acid as well as the system volumes were same both in the sample and the reference determination systems. The method after amending was suitable for the determination of antimony. Key Words: antimony; leaching amount; colorimetry; determination 1000μg/ml，唯一标识 13B29) ;孔雀绿(天津市化学试剂 锦是一种有毒的化学元素，对人体及其他生物 研究所) ;水为自制超纯水，其他试剂为分析纯。 具有慢性毒性与致癌性 [IJ 。为保障用药安全，国 家药品包装容器(材料)方法标准对各类药用玻璃 2 方法与结果