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人工microRNAs在肿瘤基因治疗中研究黄晓明
Chinese Journal of Cell Biology 2013, 35(7): 1018–1026
DOI: 10.11844/cjcb.2013.07.0300
microRNAs
1 2
( , 310013; , 325025)
microRNA22RNA, RNA
(RNA-induced silence complex, RISC), microRNA
, microRNA
microRNA
microRNA; ;
Progress of Artifi cial MicroRNAs in Cancer Gene Therapy
1 1,2 1*
Huang Xiaoming , Chen Xiang , Jia Zhenyu
1 2
( Zhejiang Academy of Medical Sciences, Hangzhou 310013, China; School of Laboratory Medicine and Life Science, Wenzhou
Medical College, Wenzhou 325025, China)
Abstract microRNA is 22nt non-coding small RNA which can mediate post-transcriptional gene silencing
via assembly into RNA-induced silence complex (RISC). MicroRNAs involve in regulation of cell growth,
differentiation, apoptosis and relate to cancer development and progression. The biogenesis, functional mechanisms
of microRNA, and its roles playing in tumors and miRNA-based cancer gene therapy are introduced in this review.
Key words microRNA; cancer; gene therapy
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7 600 000, [3-6]
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