2015 自噬的相关研究进展_魏星.pdfVIP

2564 ()2015 7 9 13 Chin J Clinicians(Electronic Edition),July 1,2015,Vol.9,No.13 1 2 Related research advance of autophagy Wei Xing1 2 1 , Li Wenxing . Shanxi Medical University, Taiyuan 030001, China; 2Department of General Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China Corresponding author: Li Wenxing, Email:163.com Abstract Autophagy is a kind of common and important life phenomenon in eukaryotic cell, and is a self-protective mechanism by maintaining intracellular environment stability, its main function is to remove and degrade itself’s damaged organelles and redundant biological macromolecules, and use the degradation products to provide energy and reconstruct cellular structure, which is a metabolic process mediated by the lysosome degradation of damaged proteins or organelles. In the steady state of cell and cell life autophagy plays a vital role. In this paper, the progress of autophagy of the meaning, classification and function of autophagy, autophagy process, autophagy signal transduction pathways and regulatory mechanism of autophagy, autophagy and multiple system diseases were summarized. Key words Autophagy; Occurrence and regulatory mechanism; Multi-system diseases 2 prote