HBsAg及Anti―HCV阳性与胆汁反流性胃炎的关系探讨.docVIP

HBsAg及Anti―HCV阳性与胆汁反流性胃炎的关系探讨 　　[摘要] 目的 探讨HBsAg及Anti-HCV阳性与胆汁反流性胃炎的相关关系。方法 查阅2006年6月―2015年5月于该院胃镜检查、并详实保存检查资料的20 316例患者的镜检结果，统计并对比HBsAg和Anti-HCV阳性与阴性，以及HBsAg阳性和Anti-HCV阳性病人之间胆汁反流性胃炎发生率的差异，进行统计学分析。结果 ①HBsAg与Anti-HCV均阴性17 041例，胆汁反流性胃炎1 292例，发生率为7.58%；HBsAg阳性与Anti-HCV阳性合计3 275例，发生胆汁反流766例，发生率为23.39%，两组差异有统计学意义（P?0.05）。②HBsAg阳性649例，胆汁反流性胃炎206例，发生率31.74%；Anti-HCV阳性2 626例，发生胆汁反流性胃炎560例，发生率21.33%，两组差异有统计学意义（P?0.01）。结论HBsAg 阳性及Anti-HCV阳性较阴性患者容易发生胆汁反流性胃炎；HBsAg阳性患者胆汁反流性胃炎发生率较Anti-HCV阳性为高 [关键词] HBsAg；Anti-HCV；胆汁反流性胃炎 [中图分类号] R657.4 [文献标识码] A [文章编号] 1674-0742（2015）12（a）-0073-03 [Abstract] Objective To explore HBsAg and Anti - HCV positive correlation with bile reflux gastritis. Methods The microscopic examination results of 20316 cases of patients who were given gastroscopy in our hospital from June 2006 to May 2015 and their examination data were kept in detail were consulted， HBsAg and Anti-HCV positive and negative， the difference of the incidence of bile reflux gastritis between HBsAg positive and Anti-HCV positive patients were compared and statistically analyzed. Results ①There were 17041 cases with HBsAg and Anti-HCV that were negative ，1292 cases with bile reflux gastritis and the incidence rate was 7.58%； HBsAg positive and Anti - HCV positive were altogether 3275 cases， 766 cases with bile reflux and the incidence rate was 23.39%， the difference between the two groups was significant （P 　　1.2 胆汁反流性胃炎的诊断及标准 以胃镜所见作为诊断依据[4]：①胃镜下可见大量黄色或黄绿色胆汁，其泡沫附着于胃壁， 部分粘附紧密形成黄色胆汁斑。②胃粘膜中度以上充血、水肿，胃窦及幽门部明显呈鲜红色，伴出血点/ 斑及糜烂性改变。③插镜后静止片刻，可见胆汁从幽门口逆行反流入胃腔 1.3 HBsAg及Anti-HCV检测方法 所有患者均抽取空腹血样离心取血清，于检验科用酶联免疫分析法（酶标仪：雷度RT-6000；乙型肝炎病毒表面抗原诊断试剂盒及丙型肝炎病毒抗体诊断试剂盒试剂盒均由沈阳惠民生物技术有限公司提供）进行HBsAg及Anti-HCV检测。由检验医师严格按说明进行试验准备、对照孔设定、加样、洗涤、加酶结合物等步骤逐一完成 1.4 统计方法 所有数据均采用SPSS10.0统计学软件进行处理， 计数资料采用（n，%）表示，采用χ2检验，以 P