Bcl-2, Bax, Akt, p-Akt, GSK3(ab), p-GSK3 and b-catenin 重庆医科大学(英文版).pdfVIP

G Model BC-3490; No. of Pages 11 ARTICLE IN PRESS The International Journal of Biochemistry Cell Biology xxx (2011) xxx–xxx Contents lists available at ScienceDirect The International Journal of Biochemistry Cell Biology j o u rn a l h o me p a ge : w w w. elsev /locate/biocel Small interfering RNA targeting integrin-linked kinase inhibited the growth and induced apoptosis in human bladder cancer cells Juan Gao a,b , Jun Zhu a,b , Hong-Yan Li a,b , Xiang-Yang Pan a,b , Rong Jiang c , Jun-Xia Chen a,b,∗ a Department of Cell Biology and Genetics, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, PR China b Molecular Medicine and Cancer Research Center, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, PR China c Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, PR China a r t i c l e i n f o a b s t r a c t Article history: Integrin-linked kinase (ILK), an intracellular serine/threonine kinase, is implicated in cell growth and Received 21 December 2010 survival, cell-cycle progression, tumor angiogenesis, and cell apoptosis. Recent studies showed that the Received in revised form 1 April 2011 expression and activity of ILK increased significantly in many types of solid tumors. However, the exact Accepted 4 May 2011 molecular mechanism of ILK underlie tumor has not been fully ascertained. The purpose of our study Available online xxx