PSY-g-PAA／APT／SA载药复合凝胶小球的制备及释药性能.pdfVIP

PSY-g—PAA／APT／SA栽药复合凝胶小球的制备及释药性能／杨会霞等 ·1 · PSY一PAA／APT／SA载药复合凝胶小球的制备及释药性能 杨会霞 ，张俊平 ，王文波 ，王爱勤 (1 中国科学院兰州化学物理研究所，兰州 730000；2 中国科学院研究生院，北京 100049) 摘要 采用离子凝胶法制备 了欧车前胶一g_聚丙烯酸／凹凸棒黏土／海藻酸钠 (PSY-g-PAA／APT／SA)载药复合 凝胶小球，以双氯芬酸钠为模型药物，考察了pH敏感性和凹凸棒黏土含量对凝胶小球的包封率、载药率、溶胀性能 和药物释放行为的影响。结果表明，当释放介质为模拟 胃液 (pH一1．2)时，药物基本不释放；而为模拟肠液(pH一 6．8)时，5h后累积释放率超过9O ，复合凝胶小球具有明显的pH敏感性。随着凝胶小球中凹凸棒黏土含量的增 加，溶胀率和药物累积释放率均减小，表明凹凸棒黏土的引入可以减缓药物的突释效应。 关键词 欧车前胶 凹凸棒黏土 凝胶小球 pH敏感性 双氯芬酸钠 中图分类号 ：Q636．1 文献标识码 ：A PreparationandtheDrugReleaseBehaviorofDiclofenacSodium-LoadedPsyllium- g-poly{acrylicacid)／Attapulgite／SodiumAlginateHydrogelCompositeBeads YANGHuixia”，ZHANGJunping，WANGWenbo，WANGAiqin (1 LanzhouInstituteofChemicalPhysics，ChineseAcademyofSciences，Lanzhou730000；2 GraduateUniversity oftheChineseAcademyofSciences，Beijing100049) Abstract Anovelpsyllium-g-poly(acrylicacid)／attapulgite／sodiumalginate(PSY-g-PAA／APT／SA)hydrogel compositebeadswerepreparedbytheionicgelationtechnique．Effectsofattapulgite(APT)contentontheswelling property，encapsulationefficiency，drugreleasebehaviorswereinvestigatedusingdiclofenacsodium(DS)asamodel drug．pH—sensitivepropertiesandinvitroreleasekineticsofDSfrom thehydrogelbeadswerealsostudied．There— sultsindicatedthatwithincreasingattapulgitecontentofthepreparedhydrogelbeads，theswellingratioandencapsu— lationefficiencyweresloweddownobviously．Moreover。DSwashardlyreleasedfrom thehydrogelbeadsinsimulated gastricfluid(pH= 1．2)，however，thecumulativereleaseratiowasover90 insimulatedintestinefluid(pH=6．8) after5h，whichindicatedthatthehydrogelbeadshadgoodpH-sensitive．Inaddition，theencapsulationefficiency， swellingratioandDScumulativereleaseratiodecreasedastheconcentrationoftheAPT increased，whichrevealedthat incor