电针调控大鼠胃酸分泌的机制论文.docVIP

　　电针调控大鼠胃酸分泌的机制论文 .freelL，P 0.01］，胃液酸度明显降低［（30±3）vs（41±1）mmol L-1 ，P 0.05］，胃液pH升高.胃粘膜Gas含量增多［（136±17）vs（73±4）ng L-1 ，P 0.01］，血浆Gas含量下降［（84±22）vs（108±30）ng g-1 ，P 0.01］，胃液Gas无变化;胃液及胃粘膜EGF含量显著升高［（3.2±1.1）vs（1.8±0.4）μg L-1 和（5.1±0.8）vs（2.4±0.4）μg g-1 ，P 0.01］，血浆EGF无变化.胃壁细胞泌酸小管不扩张，小管泡充盈不足，且数量不减少，非经非穴组及空白对照组各项指标无显著变化. 结论 电针足三里穴抑制大鼠胃G细胞Gas释放，降低血浆Gas，增加胃粘膜、胃液EGF含量;电针足三里可改变胃壁细胞超微结构，抑制胃壁细胞泌酸小管功能、降低胃酸分泌. Keyones Abstract:AIM To investigate the regulative mechanism of electroacupunture（EA）on gastric acid secretion in rats.METHODS SD rats（n=75）ized into5groups:Control group，non-point group，Sanyinjiao group，zasanli group，and unite group.All rats in consciousness ulated by electroacupuncture except control group.eanmunoassay al grouth factor（EGF）in plasma，gastric juice and gastric mucosa tis-sue.Cellular ultra-microstructure of gastric mucosa coat ission electron microscope.RESULTS After EA，it e of the fasting gastric juice significantly reduced（0.30±0.11）vs（0.63±0.12）mL，P 0.01，and the acidity of the gastric juice significantly dropped（30±3）vs（41±1）mmol L-1 ，P 0.05，and the pH of gastric juice rose.EA stimulation of zusanli led to a drop of plasmic Gas（84±22）vs（108±30）ng L-1 ，P 0.01，a rise of Gas in gastric mucous coats（136±17）vs（73±4）ng g-1 ，P 0.01，but little change in Gas in gastric juice.Besides，there e other changes ob-served.EGF of both gastric juice and gastric mucous coat in-creased（3.2±1.1）vs（1.8±0.4）μg g-1 ，P 0.01，and（5.1±0.8）vs（2.4±0.4）μg g-1 ，P 0.01respectively ic EGF didn’t change，ber.The above indexes in non-point group those of control group（P 0.05）.CONCLUSION EA stimulation of zusanli can inhibit Gas release，reduce Gas contents in plasma and gastric juice，enhance contents of EGF in gastric mucosa and juice，change ultra-microstructure of gastric gland cells，and inhibit the se-cretory function of acinotubules in paritetal cell.Finaly，The gastric acid secretion is decreased. 0 引言 中医认为，经络内属脏腑、外络肢节，胃与脾互为表里，相互影响，针刺经络腧穴，可激发内源性生理性调节，影响饮食的受纳、腐熟与运化.现代实验研究表明，针灸对胃酸