干细胞向恶性胶质瘤的趋向性迁移.pdfVIP

Neuroscience Bulletin November 30，2007，23(6)：363—369．http：／／www．neurosci．ca 363 ·Minireview· Stem cells tropism for malignant gliomas Feng XU，Jian-Hong ZHU DepartmentofNeurosurgery,ShanghaiNeurosurgical Center,Huashan HospitalofFudan University,Shanghai200040, China Abstract：Various studies have demonstrated the tremendous tropism of stem cells for malignant gliomas，making these cells a potential vehicle for delivery of therapeutic genes to disseminated glioma cells．However，little is known about the mechanisms underlying the glioma-induced tropism of stem cells．Soluble factors including chemokines or growth factors released and expressed by glioma cells at least mediate the tropism of stem cells for gliomas．Here we review the possible mechanisms of stem cells tropism for malignant gliomas． Keywords：stem cell；tropism；glioma 1 Introduction suggested that mesenchymal stem cells(MSCs)may repre- sent an alternative source of NSCs for regeneration【20’ ¨．In Malignant gliomas are the most prevalent type of pri- brain glioma models，intracranially implanted or intrave- mary brain tumors．The prognosis of patient with malig— nously injected MSCs can migrate away from the initial nant gliomas，such as glioblastoma multiforme(GBM)or injection site towards tumor beds[22-251．The ability of stem anaplasticastrocytoma,isextremelypoor,despitetheirextensive cells ofvarious lineages to migrate to gliomas have become surgical excisionandadju