二烯丙基二硫.docxVIP

化学信息学论文（设计）论文（设计）题目：二烯丙基二硫抗肿瘤机制的研究进展学 院：专 业：班 级：学生姓名：学 号：2015年12月17日论文（设计）诚信责任书本人郑重声明：本人所呈交的毕业论文（设计），是在导师的指导下独立进行研究所完成。毕业论文（设计）中凡引用他人已经发表或未发表的成果、数据、观点等，均已明确注明出处。特此声明。论文（设计）作者签名：日期：2015年12月17日二烯丙基二硫抗肿瘤机制的研究进展摘 要经过科学家们的研究表明，DADS能降低多种化学致癌物诱发的恶性肿瘤的发生率[1]。DADS对胃癌、肠癌、鼻咽癌、食管癌、乳腺癌和白血病等多种癌变具有抑制作用。本文主要调研了科学家们关于DADS对各种癌变的作用研究进展和机制。除此外，本文还查找了关于大蒜中DADS的含量及热稳定性测定。胃癌：DADS引起MGC803细胞G2/M期阻滞并诱导凋亡可能是其抗肿瘤的机制之一。鼻咽癌：DADS具有抑制人鼻咽癌CNE2细胞增殖和诱导凋亡的作用1其机制可能与Bcl-2蛋白下调1Bax蛋白表达上调导致Bcl-2 /Bax比值下降1促进Caspase 3的活化有关。乳腺癌：DADS能诱导乳腺癌细胞株MCF一7细胞凋亡1NJK信号通路抑制可能是DADS诱导其调亡的分子机制之一。白血病：DADS对KG1-α 细胞增殖抑制的机制可能与下调PKM2的表达，并使其细胞周期阻滞在G0/G1期有关。关键词：DADS（二烯丙基二硫）；凋亡；肿瘤；细胞周期AbstractAfter scientists1 studies have shown that DADS can reduce the incidence of malignant tumour of the various chemical carcinogen induced. DADS to gastric cancer1 colorectal cancer1 nasopharyngeal carcinoma1 esophageal cancer1 breast cancer and leukemia1 etc can inhibit cancer. This article mainly research the scientists of DADS on research progress and mechanisms of different types of cancer. In addition1 this article also found in garlic and thermal stability and the content of DADS. Cancer of the stomach: DADS MGC803 cells in G2 / M phase of block and induction of apoptosis may be one of its antitumor mechanism. Nasopharyngeal carcinoma: DADS could inhibit the proliferation and induce the apoptosis of human nasopharyngeal carcinoma CNE2 cells1 the mechanism may be related to the Bcl - 2 protein1 Bax protein expression increases resulting in a decline in the Bcl - 2 / Bax ratio and promote the activation of Caspase 3. A breast cancer: DADS can induce breast cancer cell line MCF 7 cell apoptosis1 NJK signaling pathway inhibition may be one of the molecular mechanism of DADS induce its apoptosis. Leukemia: DADS for KG1 alpha cell proliferation inhibition mechanism may be related to downgrade PKM2 expression1 and cell cycle arrest in G0 / G1 phase.Keywords: DADS（Diallyl disulfide）; Apoptosis; Tumor; The cell cycle前 言大蒜及其烯丙基硫化物抗癌作用的研究日益被受关注研