参蛤益肺胶囊对慢性阻塞性肺疾病大鼠炎症因子的影响.PDFVIP

2007年 2月第 14卷第 2期 中国中医药信息杂志 ·37· 参蛤益肺胶囊对慢性阻塞性肺疾病 大鼠炎症因子的影响 1 1 2 1 1 1 1 孙 钢 ,吕志坚 ,茅彩萍 ,陈 宇 ,浦明之 ,周运海 ,指导：何焕荣 (1.苏州市中医院,江苏 苏州 215003；2.苏州大学基础医学院,江苏 苏州 215006) 摘要：目的 观察参蛤益肺胶囊对慢性阻塞性肺疾病(COPD)大鼠气道炎症因子及气道病理形态的影响。方法 SD 大鼠 60 只,随机分为正常对照组、COPD 模型组、金水宝对照组及参蛤益肺胶囊低、中、高剂量组,烟熏加脂多糖 法造模,观察各组治疗后肺泡灌洗液(BALF)中白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)水平及气道病理组织学 变化。结果 参蛤组 IL-8、TNF-α水平比模型组减低(P 0.01),气道病理改变较轻。结论 参蛤益肺胶囊具有一定 的抑制COPD气道炎症的作用。 关键词：参蛤益肺胶囊；慢性阻塞性肺疾病；气道炎症；白细胞介素8；肿瘤坏死因子α 中图分类号：R285.5 文献标识码：A 文章编号：1005-5304(2007)02-0037-02 Effect of Shengeyifei Capsule on Inflammatory Mediators in Rat with Chronic Obstructive Pulmonary Disearse 1 1 2 SUN Gang , LU Zhi-jian , MAO Cai-ping , et al (1.Suzhou Hospital of TCM, Suzhou 215003, China；2.Basic Medical College of Suzhou University, Suzhou 215006, China) Abstract ：Objective To observe the effect of Shengeyifei capsule on the inflammatory mediators in the airway and the pathology of the airway in the rat with chronic obstructive pulmonary diserse (COPD). Methods 60 SD rats were divided randomly into normal group, COPD model group, Jinshuibao control group and Shengeyifei groups. The COPD model was established by smoking and infusing lipopoly- saccharide (LPS). The level of interleukin-8 (IL-8) and tumor necrosis factor α (TNF-α) in bronchoalveolar lavage fluid (BALF) were measured and the pathology of the airway and lung tissue was observed after treatment on the rats. Result The levels of IL-8 and TNF-α in Shengeyifei groups were lower than in COPD model group (P 0.01),