氨糖胶囊安全性毒理学试验.PDFVIP

2384 　2011 12 　18 　 12 　Practical Preventive Medicine, Dec.2011, Vol 18, No.12 :1006-3110(2011)12-2384-04 氨糖胶囊的安全性毒理学试验 徐　冰, 张　炎, 王海玉, 张聪恪, 李　立, 陈东方 　　:　　。 　　(M TD), (Ames、 ), 30 d。 　　 、 MTD 10.0 g kg·bw。 Ames 、 。 30 d , 、4.0 g kg·bw(100 )。 　　, 。 :　氨糖胶囊;安全性毒理学;小鼠;大鼠 :R-331　　　　　:B Toxicologi cal Research on Safety of Antang Capsule 　X U Bing, ZHAN G Yan, WANG Hai-y u, et al.(Department of Tox- icology , Henan Provincial Center f or D i ea e Control and Prevention, Zhengzhou 450016, Henan, China) Abstract:　Objective 　To observe the t oxic ity of Antang capsule.　Methods　 MTD;Test of genet ic t ox ic ity (Test of Ames, bone marrow c el l micronuc leus and sperm abnormality);30 days feeding test.　Results　 MT D of Antang capsule was great er t han 10.0 g kg·bw to rats and mice.The result s were negat ive in Ames t est, mic e bone marrow cell mic ronucleus test, and mice sperm abnormality test.In the 30 day s f eeding experiment, the test parameters, when the maximum dose group of female and male rats were 4.0 g kg ·bw (equal t o 100 t imes of commended dose in human body), had no significant difference compared w it h the control group.　Conclusions 　 Ant ang capsule has no obv ious t oxic ity under t his ex periment condit ion. Key words:　Ant ang capsule;Safety tox icology;Mice;Rat s 　　 、 2 , 3 。 。 , 。 1.2　急性毒性试验 , 1.2.1　小鼠急性毒性试验　 , 18～ 22 g, , 10 , , [1] , 。 :0154717, SPF 。 :SYX ()2007- , 0008, 。 , 10.0 g [2,3] , 。 kg·bw。 50.0 g 100 ml 。