手性环氧氯丙烷的制备.pdfVIP

2009 年第 29 卷 有 机 化 学 Vol. 29, 2009 第 8 期, 1209～1216 Chinese Journal of Organic Chemistry No. 8, 1209～1216 ·综述与进展· 手性环氧氯丙烷的制备及其药物应用 卢定强*,a,b 涂清波 a 凌岫泉 a 王 俊 a 李衍亮 a 党安旺 a 任 伟 c 韦 萍 c (a 南京工业大学药学院 南京 210009) (b 江苏省药物研究所 南京 210009) (c 南京工业大学生物与制药工程学院 南京 210009) 摘要 手性环氧氯丙烷作为医药和化工等领域的重要中间体, 可以从廉价的外消旋体中分离得到, 具有广阔的市场前 景. 综述了它的生物和化学法制备进展, 及其在药物合成方面的应用, 并展望了其制备工艺的发展趋势. 关键词 手性; 环氧氯丙烷; 制备; 药物 Preparation and Drug Application of Chiral Epichlorohydrin Lu, Dingqiang*,a,b Tu, Qingboa Ling, Xiuquana Wang, Juna Li, Yanlianga Dang, Anwanga Ren, Weic Wei, Pingc a ( School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing 210009) (b Jiangsu Institute of Materia Medica , Nanjing 210009) (c College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009) Abstract Chiral epichlorohydrin is an important intermediate in medicine and chemical industry fields, which has a wide market prospect and can be separated from racemate with low price. This review summa- rizes the progress in biological and chemical preparation of chiral epichlorohydrin and its application to drug synthesis. Furthermore, some promising research trends are proposed. Keywords chiral; epichlorohydrin; preparation; drug 手性环氧氯丙烷是一种重要的三碳手性合成子, 在