减少胶屑提高胶塞洗涤澄明度.pdfVIP

• 286 • 黑龙江医~ HeiLongJiang Medicine Jo盯nal VOl. 17 NO. 4 2004 减少股屑提高胶塞洗涤澄明皮 张阳敏央提策 哈药集团制药总厂(150086) 摘摆 阔的:为了保证成品药品的澄明度，寻找控制胶屑产生的原因。方法:分别从设备、人员、 材质三个不同方面进行考察，找出造成胶屑的主要原因，改进设备，强化人员培训，配合厂家寻找好 的工t; 配方。结论:通过改进使胶屑占毛点百分率由原来78.9% 降到66.52% ;每次平均胶屑个数由 4. 08降至2.07 0 ;SOP; 关键诩 百分率;澄明皮 Reduce Rubber Clipping and Increase Lirnpid Degree of the Rubber Stopples Zhang Limin ,et a l. The General Factory 0/ Harbin Pharmaceuticαl Grou户 Holding Co. ,LtdCHarbin 150086) Abstract Objective: Ensure the of the lucidity of the finished leechdom ,find out the causa- tion that cause the rubber clipping. Method: Make researches on the facilities ,operators and mate伽 rials separately to find out the causation that cause the rubber clipping. Improve facilities , strengthen the training of the operators and help the factory to ameliorate the technics. Results: By improving the technics ,the percentage of the rubber clipping has dropped fròm 78. 9 % to 66. 52%. The average amount of the rubber clipping has dropped from 4.08 to 2.07 at a time. Key words Percentage; Limpid Degree; SOP 积归一法(3) 检测食最可站:98.5% 以上，可以满足制 使用燕馆7}( 洗涤，揣饼干燥，得到2- 甲酌氟慕w 嚼嗖 药中间体的含最要要求。 基斗乙酸。 3 实验锚果 4 讨论 经实验后得到收率结果见表10 本方法合成的公甲酷氨基嚼咄蒜-4- 乙酸甜度 表1 2町甲酿氨基嚓蟆摹斗乙酸收率 高，杂质含最低。原材料容易获得，收率也比较理想， 戚本较低，涌合工业化生产。