异甘草酸镁治疗抗结核药引起药物性肝炎临床疗效探析.doc

异甘草酸镁治疗抗结核药引起药物性肝炎临床疗效探析 　　[摘要] 目的 探讨异甘草酸镁治疗抗结核药引起的药物性肝炎的疗效。方法 随机将方便选取2012年1月―2016年12月该院收治的61例抗结核药所致药物性肝炎患者分为两组。实验组31例，患者用药异甘草酸镁；对照组30例，患者复方甘草酸单铵S。观察两组疗效。 结果 治疗后，实验组患者肝功能指标ALT、AST、γ-GT和ALP的改善效果均优于对照组，治疗总有效率（96.8%）也明显高于对照组（80.0%），差异有统计学意义（P0.05）。结论 异甘草酸镁具有降酶护肝的作用，以此治疗抗结核药引起的药物性肝炎疗效确切，安全可靠，值得临床推广使用 [关键词] 异甘草酸镁；药物性肝炎；肝功能 [中图分类号] R453 [文献标识码] A [文章编号] 1674-0742（2017）02（a）-0137-03 [Abstract] Objective To discuss the curative effect of magnesium isoglycyrrhizinate in treatment of drug hepatitis caused by the antitubercular agents. Methods Convenient selection 61 cases of patients with drug hepatitis caused by the antitubercular agents in our hospital from January 2012 to December 2016 were randomly divided into two groups with 31 cases in each， the experimental group were treated with isoglycyrrhizinate， while the control group were treated with Compound ammonium glycyrrhetate， and the curative effect of the two groups was observed. Results After treatment， the liver function indexes ALT， AST， γ-GT and ALP improvement effect was better than those in the control group， and the total treatment effective rate in the experimental group was obviously better than that in the control group（96.8% vs 80.0%）， and the difference had statistical significance（P0.05）. Conclusion Isoglycyrrhizinate has the effect of reducing serum lipid andenzymes， and the curative effect of it in treatment of drug hepatitis caused by the antitubercular agents is definite， and it is safe and reliable， which is worth clinical promotion and application. [Key words] Isoglycyrrhizinate； Drug hepatitis； Liver function 药物性肝炎是指药物及其相关代谢产物所引起的肝脏损害。现有药物中，明确可直接或间接引起本病者已有近千种，其中就包括抗结核病重要药物吡嗪酰胺、异烟肼、利福平等[1]。数据统计，结核病化疗所致肝损伤约占所有药物性肝损伤的10%，平均发病率为7%～31%，已经成为导致结核患者中止化疗的主要原因[2]。异甘草酸镁是天然甘草酸立体异构体镁盐，生物医学离体试验研究发现，该品对慢性肝损伤和免疫性肝损害均具有保护和治疗作用。该研究以2012年1月―2016年12月该院收治的61例抗结核药所致药物性肝炎患者为研究对象，对异甘草酸镁治疗抗结核药物所致药物性肝炎的临床疗效进行分析和探究，现报道如下 1 资料与方法 1.1 一般资料 方便选取该院收治的61例抗结核药所致药物性肝炎患者为研究对象。全部患者均于结核化疗期间出现不同程度的肝炎症状，化疗前患者肝功能正常，化