HIV存储库_清除HIV的障碍与目标_温敏.pdfVIP

HIV存储库:清除HIV的障碍与目标 1, 2 1 1 2, 3 温敏 , 赵竞 ,马克坚 , 肖小河 [ ] 高效抗逆转录病毒治疗(HAART)的广泛使用很大程度上控 H IV/A IDS患者的 HIV, 使血浆 HIV RNA下降到检出限之下, 显著降低了A IDS及其相关病症的发生, 但实践证明感染者体内仍有病毒潜 + 伏存储库静息型 CD4 T细胞 HIV 潜伏存储库是主要的存储库, 同时也是根除H IV 的主要障碍, 具 有半衰期长持续时间长容易反弹等特点, 现有的治疗策略无法对其清除, 寻找有效的抑 H IV存储 库的治疗策略已成为治疗H IV/A IDS的重要目标 + [] HIV;潜伏存储库; 静息型 CD4 T细胞 [] R 512. 91 [] A [] 1001- 7089( 2011) 04- 0312- 03 LatentReservoirs ofHIV: Obstacles and Goal to theEradication ofV irus 1, 2 1 1 2, 3 WENM in , ZHAO Jing , MA Kejian, X IAO X iaohe ( 1Yunan Institute of TraditionalChineseM edicine andM ateriaM edica,K unm ing 650223, China; 2Chengdu University of TraditionalChineseM edicine, Chengdu 610075, China; 3PLA Institute of ChineseM ateria M edica, osp ital 302 of PLA, Beij ing 100039, China) [Corresponding author] X IAO X iaohe, Email: pharmacy302 126. com [Abstract] W ith the advent ofhighly active antiretroviral therapy (HAART), which could lead a substantial decline in the incidence of acquired mi munodeficiency syndrome ( AIDS) and A IDSrelated mortality, control of viral replication is now possible. However, the persistence of various viral reservoirs in infected individuals ex + ists. A pool of latently infected cells in the resting CD4 T cell compartmenthas been oneof themost exten sively studied to date and is considered tobe amajor mi pedmi ent toH IV eradication. It has been proved that long intrinsichalflife of such a latentHIV reservoir lead tobounceofdisease easily. Ithas been proved the + current strategies for the elmi ination of latent infection an