非霍奇金淋巴瘤中CD40、CD40L的表达及意义.pdfVIP

·294 · GuizhouMedicalJourna1，2010，Vo1．34，No．4 非霍奇金淋巴瘤中CD40、CD40L的表达及 意义 遵义医学院附属医院血液内科(563000)任 明强 陈 琦 李佑福 摘 要 目的 探讨非霍奇金淋巴瘤(NHL)中CD40、CD40L表达与NHL预后间的关系及 意义。方法 免疫组 织化学法检 测 50例非霍奇金淋巴瘤、22例淋巴结反应性增生组织中CD40、 CD40L的表达。结果 (1)NHL中CD40过度阳性率(66．0 )显著高于淋巴结反应性增生(36．4 )， P0．05；NHL中CD40L过度 阳性率(20．0 )显著低于淋 巴结反应性增生(63．6 )，P0．05。(2) NHL中CD4O与 CD40L表达呈负相关，r一一0．486，P0．05。(3)NHL患者 CD4O、CD40L的过度 阳性率与恶性程度 、结外浸润及 临床分期均显著相关 ，P0．05。结论 (1)CD40、CD40L过度 阳性率 与恶性程度、结外浸润及临床分期密切相关，其可能与NHL侵袭性及预后有关。(2)NHL中CD4O 表达的增高、CD40L表达的减少可能是影响其发病的因素之一。 关键词 非霍奇金淋巴瘤 CD40 CD40配体 ExpressionsandsignificanceofCD40，CD40L in non-hodgkin lymphomaRenMing—qiang，Chen Qi，LiYou-fu．DepartmentofHematology，T^PAffiliatedHospitalofZunyiMedicalCollege， Zunyi563000，Guizhou，China Abstract 0bjective TostudytherelationshipbetweentheexpressionsofCD40，CD4OLinthe tissuesofnon—hodgkinlymphoma(NHL)andprognosis，clinicalimplicationofpatientswithNH乙． MethodsTheexpressionofCD40．CD40L in 50 NHL tissuesand 2O reactivehyperplasiaoflymph nodetissuesweredeterminedbyimmunohistochemicalmethod．Results(1)CD40positiveoverexpres— sionrateinNHLsamples(66，0 )washigherthanthatofinreactivehyperplasiaoflymphnodesam— pies(36．4 )(P0．05)，CD40LpositiveoverexpressionrateinNHLsamples(20．0％)waslower thanthatofinreactivehyperplasiaoflymphnodesamples(63．6 ) (PO．05)．(2)Therewereneg— ativecorrelationsbetweenCD40andCD40L expressionsinthose(r 一0．486，P0．05)．(3)There weresignificantcorrelationsbetweenthepositiveoverexpression ratesofCD40，CD4OL，andmalig— nantdegree，infiltrationbesidelymphnodeorganandclinicalstagesinNHL patients．Conclusion (1) ThereareclosecorrelationsbetweenCD40，CD40L andmalignantdegree，infiltration besidelymph nodeorganandclinicalstages，whichcanlikelybecorrelativeinjudgingtheNHLprognosisandinfes- tation．(2)HighCD40expressionsandlowCD40Lexpressionsmayprobablybeoneofetiologicfac— torsofNHL． Keywords NonHodgkinLymphoma CD40 CD40L